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Volume 38 Issue 12
Dec.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(12): 2841-2845

Advances in the mechanism of action of silent information regulator 1 in alcoholic liver disease and related pharmaceutical studies

DOI: 10.3969/j.issn.1001-5256.2022.12.030
  • 1.

    The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450018, China

  • 2.

    Spleen, Stomach and Hepatobiliary Department, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (Joint Fund) (U1504825);

Key Scientific Research Projects of Colleges and Universities in Henan Province (20A360014);

Henan Provincial Top talents training Program of Traditional Chinese Medicine (Yuwei Traditional Chinese Medicine 2021 No.15)

More Information
  • Corresponding author: LIU Jiangkai, xmlc001@126.com (ORCID: 0000-0002-1529-5089)
  • Received Date: 2022-05-07
  • Accepted Date: 2022-06-17
  • Published Date: 2022-12-20
    Abstract
  • Alcoholic liver disease (ALD) is one of the main chronic liver diseases in the world, and the prevalence rate of ALD is increasing year by year in China, with a trend of earlier age of onset. Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase and plays a significant role in cell metabolism, oxidative stress, and inflammation, and it is expected to become a new therapeutic target for ALD. This article reviews the mechanism of action of SIRT1 in ALD and related pharmaceutical studies, in order to provide a reference and strategies for further research on the pathogenesis of ALD and its potential therapeutic targets.

     

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