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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 1
Jan.  2023
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Article Contents

Research advances in tenofovir alafenamide fumarate in treatment of special chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2023.01.024
Research funding:

Chronic Hepatitis B Clinical Research Project (IN-CN-320-5837)

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  • Corresponding author: XIN Yongning, xinyongning@163.com(ORCID: 0000-0002-3692-7655)
  • Received Date: 2022-07-15
  • Accepted Date: 2022-09-19
  • Published Date: 2023-01-20
  • There are a large number of individuals with HBV infection in China, which seriously endangers public health safety. As a first-line drug used in clinical practice, tenofovir alafenamide fumarate (TAF) has the characteristics of strong efficacy, low drug resistance, and bone and kidney safety. This article summarizes the role of TAF in patients with special types of chronic hepatitis B, such as low-level viremia, multidrug resistance, pregnancy, liver failure, and liver transplantation, and the analysis shows that TAF can reduce viral load in patients with low-level viremia to achieve virologic response, provide new regimens for patients with drug resistance, block mother-to-child transmission, reduce the mortality rate of patients with end-stage liver disease, and improve renal function in patients with chronic kidney disease.

     

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