ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 1
Jan.  2023
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Article Contents

Research advances in the impact of phthalates on cholestatic liver disease

DOI: 10.3969/j.issn.1001-5256.2023.01.035
Research funding:

National Natural Science Foundation of China (82073566);

the Program of Excellent Young Talents in Universities of Anhui Province (gxyq2019014);

Co-sponsored by Clinical Pharmacy and Pharmacology (2020)

More Information
  • Corresponding author: WANG Jianqing, jianqingwang81@126.com (ORCID: 0000-0002-7935-9520)
  • Received Date: 2022-05-02
  • Accepted Date: 2022-07-25
  • Published Date: 2023-01-20
  • Cholestatic liver disease is a common hepatobiliary disease caused by bile deposition in the liver due to the disorders of bile production, excretion, and metabolism. At present, the pathogenic factors for cholestatic liver disease have not been fully elucidated, but some researchers believe that environmental factors may play an important role in it. As environmental pollutants, phthalic acid esters (PAE) have been confirmed to interfere with human endocrine system, exert a potential toxic effect on the human body, endanger liver and kidney function, and increase the risk of intrahepatic cholestasis. On this basis, this article reviews the association between PAE and cholestatic liver disease and summarizes related clinical studies, animal experimental studies, in vitro experimental studies, and potential mechanisms, so as to provide ideas and references for the prevention and clinical treatment of cholestatic liver disease.


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