中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 3
Mar.  2023
Turn off MathJax
Article Contents

Diagnosis and treatment of autoimmune hepatitis: The indispensable role of pathology

DOI: 10.3969/j.issn.1001-5256.2023.03.004
Research funding:

National Natural Science Foundation of China (81970454)

More Information
  • Corresponding author: YANG Yongfeng, yyf1997@163.com (ORCID: 0000-0002-3214-0038)
  • Received Date: 2022-12-31
  • Accepted Date: 2023-02-07
  • Published Date: 2023-03-20
  • Autoimmune hepatitis has become the main type of non-infectious hepatitis in China. This article summarizes its characteristic manifestations and the current status of diagnosis and treatment and points out that pathological histology plays an indispensable role in the diagnosis and treatment of autoimmune hepatitis.

     

  • loading
  • [1]
    LIU HL, YANG YF, XIONG QF, et al. Etiological analysis of hepatopathy of unknown etiology in 470 cases undergoing routine liver biopsy examination[J]. Chin J Hepatol, 2019, 27(11): 885-889. DOI: 10.3760/cma.j.issn.1007-3418.2019.11.012.

    刘红丽, 杨永峰, 熊清芳, 等. 470例行肝穿刺活组织检查的不明原因肝病的病因分析[J]. 中华肝脏病杂志, 2019, 27(11): 885-889. DOI: 10.3760/cma.j.issn.1007-3418.2019.11.012.
    [2]
    ZHANG HY, MA X. Diagnosis and management of autoimmune hepatitis with acute presentation[J]. Chin J Hepatol, 2012, 20(5): 396-397. DOI: 10.3760/cma.j.issn.1007-3418.2012.05.021.

    张海燕, 马雄. 急性起病自身免疫性肝炎的诊断与治疗[J]. 中华肝脏病杂志, 2012, 20(5): 396-397. DOI: 10.3760/cma.j.issn.1007-3418.2012.05.021.
    [3]
    LI YN, MA H, ZHOU L, et al. Autoimmune hepatitis-related cirrhosis: clinical features and effectiveness of immunosuppressive treatment in chinese patients[J]. Chin Med J (Engl), 2016, 129(20): 2434-2440. DOI: 10.4103/0366-6999.191760.
    [4]
    VILLALTA D, GIROLAMI E, ALESSIO MG, et al. Autoantibody profiling in a cohort of pediatric and adult patients with autoimmune hepatitis[J]. J Clin Lab Anal, 2016, 30(1): 41-46. DOI: 10.1002/jcla.21813.
    [5]
    GORDON V, ADHIKARY R, APPLEBY V, et al. Diagnosis, presentation and initial severity of Autoimmune Hepatitis (AIH) in patients attending 28 hospitals in the UK[J]. Liver Int, 2018, 38(9): 1686-1695. DOI: 10.1111/liv.13724.
    [6]
    SEBODE M, WEILER-NORMANN C, LIWINSKI T, et al. Autoantibodies in autoimmune liver disease-clinical and diagnostic relevance[J]. Front Immunol, 2018, 9: 609. DOI: 10.3389/fimmu.2018.00609.
    [7]
    TERZIROLI BERETTA-PICCOLI B, MIELI-VERGANI G, et al. Autoimmune hepatitis: Serum autoantibodies in clinical practice[J]. Clin Rev Allergy Immunol, 2022, 63(2): 124-137. DOI: 10.1007/s12016-021-08888-9.
    [8]
    GATSELIS NK, ZACHOU K, KOUKOULIS GK, et al. Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics[J]. World J Gastroenterol, 2015, 21(1): 60-83. DOI: 10.3748/wjg.v21.i1.60.
    [9]
    YANG XJ, YANG YF, ZHONG YD. The value of serum immunoglobulin and autoantibodies in the diagnosis of autoimmune hepatitis[J]. Chin Hepatol, 2018, 23(12): 1084-1086. DOI: 10.14000/j.cnki.issn.1008-1704.2018.12.012.

    杨小娇, 杨永峰, 钟艳丹. 血清免疫球蛋白与自身抗体检测在自身免疫性肝炎诊断中的价值[J]. 肝脏, 2018, 23(12): 1084-1086. DOI: 10.14000/j.cnki.issn.1008-1704.2018.12.012.
    [10]
    MIAO Q, CHEN XY. Liver histopathological diagnosis of autoimmune hepatitis[J]. J Clin Hepatol, 2020, 36(4): 728-730. DOI: 10.3969/j.issn.1001-5256.2020.04.003.

    苗琪, 陈晓宇. 自身免疫性肝炎的肝组织病理学诊断[J]. 临床肝胆病杂志, 2020, 36(4): 728-730. DOI: 10.3969/j.issn.1001-5256.2020.04.003.
    [11]
    NGUYEN CANH H, HARADA K, OUCHI H, et al. Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients[J]. J Clin Pathol, 2017, 70(11): 961-969. DOI: 10.1136/jclinpath-2016-204271.
    [12]
    AIZAWA Y, ABE H, SUGITA T, et al. Centrilobular zonal necrosis as a hallmark of a distinctive subtype of autoimmune hepatitis[J]. Eur J Gastroenterol Hepatol, 2016, 28(4): 391-397. DOI: 10.1097/MEG.0000000000000545.
    [13]
    WANG PS, WANG JY, HU XQ, et al. Clinical and histopathologic features of drug-induced autoimmune hepatitis[J]. Chin J Dig, 2014, 34(2): 105-108. DOI: 10.3760/cma.j.issn.0254-1432.2014.02.008.

    王丕胜, 王吉耀, 胡锡琪, 等. 药物诱导的自身免疫性肝炎的临床和病理特点[J]. 中华消化杂志, 2014, 34(2): 105-108. DOI: 10.3760/cma.j.issn.0254-1432.2014.02.008.
    [14]
    BJÖRNSSON ES, NAVARRO VJ, CHALASANI N. Liver injury following tinospora cordifolia consumption: Drug-Induced AIH, or de novo AIH?[J]. J Clin Exp Hepatol, 2022, 12(1): 6-9. DOI: 10.1016/j.jceh.2021.11.014.
    [15]
    FEBRES-ALDANA CA, ALGHAMDI S, KRISHNAMURTHY K, et al. Liver fibrosis helps to distinguish autoimmune hepatitis from DILI with autoimmune features: A review of twenty cases[J]. J Clin Transl Hepatol, 2019, 7(1): 21-26. DOI: 10.14218/JCTH.2018.00053.
    [16]
    TSUTSUI A, HARADA K, TSUNEYAMA K, et al. Histopathological analysis of autoimmune hepatitis with "acute" presentation: Differentiation from drug-induced liver injury[J]. Hepatol Res, 2020, 50(9): 1047-1061. DOI: 10.1111/hepr.13532.
    [17]
    ALVAREZ F, BERG PA, BIANCHI FB, et al. International autoimmune hepatitis group report: review of criteria for diagnosis of autoimmune hepatitis[J]. J Hepatol, 1999, 31(5): 929-938. DOI: 10.1016/s0168-8278(99)80297-9.
    [18]
    HENNES EM, ZENIYA M, CZAJA AJ, et al. Simplified criteria for the diagnosis of autoimmune hepatitis[J]. Hepatology, 2008, 48(1): 169-176. DOI: 10.1002/hep.22322.
    [19]
    QIU D, WANG Q, WANG H, et al. Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients[J]. J Hepatol, 2011, 54(2): 340-347. DOI: 10.1016/j.jhep.2010.06.032.
    [20]
    LOHSE AW, SEBODE M, BHATHAL PS, et al. Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology[J]. Liver Int, 2022, 42(5): 1058-1069. DOI: 10.1111/liv.15217.
    [21]
    HARADA K, HIEP NC, OHIRA H. Challenges and difficulties in pathological diagnosis of autoimmune hepatitis[J]. Hepatol Res, 2017, 47(10): 963-971. DOI: 10.1111/hepr.12931.
    [22]
    Chinese Society of Hepatology, Chinese Medical Association. Guidelines on the diagnosis and management of autoimmune hepatitis (2021)[J]. J Clin Hepatol, 2022, 38(1): 42-49. DOI: 10.3760/cma.j.cn112138-20211112-00796.

    中华医学会肝病学分会. 自身免疫性肝炎诊断和治疗指南(2021)[J]. 临床肝胆病杂志, 2022, 38(1): 42-49. DOI: 10.3760/cma.j.cn112138-20211112-00796.
    [23]
    AL-CHALABI T, HENEGHAN MA. Remission in autoimmune hepatitis: what is it, and can it ever be achieved?[J]. Am J Gastroenterol, 2007, 102(5): 1013-1015. DOI: 10.1111/j.1572-0241.2007.01147.x.
    [24]
    HARRISON L, GLEESON D. Stopping immunosuppressive treatment in autoimmune hepatitis (AIH): Is it justified (and in whom and when)?[J]. Liver Int, 2019, 39(4): 610-620. DOI: 10.1111/liv.14051.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(1)

    Article Metrics

    Article views (543) PDF downloads(196) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return