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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 3
Mar.  2023
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Article Contents

Research advances in effective constituents of traditional Chinese medicine in intervention of autoimmune hepatitis-related signaling pathways

DOI: 10.3969/j.issn.1001-5256.2023.03.029
Research funding:

National Natural Science Foundation of China (81573933);

Natural Science Foundation of Henan Province (222300420490);

Traditional Chinese Medicine Discipline Construction Project of Henan Province Characteristic Backbone Discipline (STG-ZYXKY-2020017)

More Information
  • Corresponding author: LIU Guangwei, Liuguangwei1975@163.com(ORCID: 0000-0002-6641-1625)
  • Received Date: 2022-07-15
  • Accepted Date: 2022-08-26
  • Published Date: 2023-03-20
  • As a chronic liver inflammation disease caused by the lack of immune tolerance, autoimmune hepatitis is regulated by various signaling pathways, such as the NF-κB/NLRP3 pathway, the SIRT1/Nrf2/HO-1 pathway, the Hippo-YAP/TAZ pathway, the JAK/STAT pathway, the PI3K/Akt pathway, and the TRAF6/JNK pathway. These pathways can play a role against autoimmune hepatitis by participating in the processes including the proliferation and apoptosis of cytokines, immune response, and oxidative stress. In view of the problems of suboptimal response, obvious adverse reactions, and high recurrence rate in the clinical application of hormones and immune preparations for the treatment of autoimmune hepatitis, this article summarizes the research articles on autoimmune hepatitis-related signaling pathways and the mechanism of effective constituents (glycosides, terpenoids, flavonoids, quinones, and phenols) in traditional Chinese medicine intervening against the disease process of autoimmune hepatitis through the above signaling pathways, in order to provide a theoretical basis for scientific and effective utilization of effective constituents in traditional Chinese medicine to develop anti-autoimmune hepatitis drugs.

     

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