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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 3
Mar.  2023
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Article Contents

Role of gasdermin D in the pathological progression of liver diseases

DOI: 10.3969/j.issn.1001-5256.2023.03.035
Research funding:

National Natural Science Foundation of China (82274434);

National Natural Science Foundation of China (81774236);

National Natural Science Foundation of China (81960841);

Guangxi Natural Science Foundation (2018GXNSFGA281002)

More Information
  • Corresponding author: GUI Xiongbin, Guixb2008@163.com (ORCID: 0000-0002-6417-497X)
  • Received Date: 2022-08-20
  • Accepted Date: 2022-10-16
  • Published Date: 2023-03-20
  • As a novel star molecule, gasdermin D (GSDMD) plays an important role in the amplification of immune inflammatory response and the process of pyroptosis. After being cleaved and activated by caspase-1, the N-terminal of GSDMD is rapidly released, which anchors on the cell membrane and forms pores, thereby leading to pyroptosis, accompanied by the release of a large amount of the strong proinflammatory factors IL-1β and IL-18. Acute/chronic liver inflammatory response and cell death are the common pathological features of liver diseases such as viral hepatitis, alcoholic liver disease, nonalcoholic fatty liver disease, autoimmune liver disease, liver failure, and hepatocellular carcinoma. This article summarizes the basic structural characteristics of GSDMD and elaborates on its important role in the pathological progression of various liver diseases. In addition, it is proposed that prevention and treatment strategies with GSDMD as a potential therapeutic target can provide new ideas for further studies on the clinical prevention and treatment of liver diseases.

     

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