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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 10
Oct.  2023
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Article Contents

The definition and pathogenesis of acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2023.10.003
Research funding:

National Natural Science Foundation of China (82170619);

National Natural Science Foundation of China (81970544);

Program for Young Outstanding Academic Leaders (20XD1422600);

Shanghai Rising Stars of Medical Talent Youth Development Program Outstanding Youth Medical Talents (SHWJRS[2021]-99);

Shanghai talent development fund (2020097);

Shanghai Municipal Key Clinical Specialty (shslczdzk01103)

More Information
  • Corresponding author: XIANG Xiaogang, shine-xxg@163.com (ORCID: 0000-0003-0999-2950)
  • Received Date: 2023-07-11
  • Published Date: 2023-10-30
  • The concept of acute-on-chronic liver failure (ACLF) has been widely accepted by scholars around the world since it was proposed nearly 30 years ago, but there are still no uniform criteria for the definition and diagnosis of ACLF worldwide. In recent years, differences have been gradually narrowed and a consensus has been reached in the key features of the disease description for ACLF, such as the underlying chronic liver diseases, acute intrahepatic or extrahepatic injury, acute liver function decompensation, extrahepatic organ failure, high short-term mortality rates, and reversible course of the disease. The pathogenesis of ACLF remains unclear, and most studies focus on systemic inflammatory response and immune dysfunction.

     

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