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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 10
Oct.  2023
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Article Contents

Evolution of the clinical scoring and classification system for acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2023.10.004
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  • Corresponding author: LI Rongkuan, dalianlrk@126.com (ORCID: 0000-0002-2927-7017)
  • Received Date: 2023-07-10
  • Published Date: 2023-10-30
  • Acute-on-chronic liver failure (ACLF) has complex pathogeneses, difficulties in clinical treatment, and poor prognosis. Due to the differences in the distribution of chronic liver diseases in different countries and regions, more than ten scoring and classification systems for ACLF have been proposed in the past few decades, indicating that there are great differences in the definition, scoring, and classification of ACLF. By analyzing the characteristics of several widely used scoring and classification systems, this article discusses their evolution process and the classification criteria applicable to China, so as to provide a reference for optimizing treatment regimens.

     

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  • [1]
    ASRANI SK, SIMONETTO DA, KAMATH PS. Acute-on-chronic liver failure[J]. Clin Gastroenterol Hepatol, 2015, 13( 12): 2128- 2139. DOI: 10.1016/j.cgh.2015.07.008.
    [2]
    REVERTER E, TANDON P, AUGUSTIN S, et al. A MELD-based model to determine risk of mortality among patients with acute variceal bleeding[J]. Gastroenterology, 2014, 146( 2): 412- 419.e 3. DOI: 10.1053/j.gastro.2013.10.018.
    [3]
    ARTRU F, LOUVET A, RUIZ I, et al. Liver transplantation in the most severely ill cirrhotic patients: A multicenter study in acute-on-chronic liver failure grade 3[J]. J Hepatol, 2017, 67( 4): 708- 715. DOI: 10.1016/j.jhep.2017.06.009.
    [4]
    SARIN SK, CHOUDHURY A, SHARMA MK, et al. Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific association for the study of the liver(APASL): An update[J]. Hepatol Int, 2019, 13( 4): 353- 390. DOI: 10.1007/s12072-019-09946-3.
    [5]
    CHOUDHURY A, JINDAL A, MAIWALL R, et al. Liver failure determines the outcome in patients of acute-on-chronic liver failure(ACLF): Comparison of APASL ACLF research consortium(AARC) and CLIF-SOFA models[J]. Hepatol Int, 2017, 11( 5): 461- 471. DOI: 10.1007/s12072-017-9816-z.
    [6]
    MEZZANO G, JUANOLA A, CARDENAS A, et al. Global burden of disease: Acute-on-chronic liver failure, a systematic review and meta-analysis[J]. Gut, 2022, 71( 1): 148- 155. DOI: 10.1136/gutjnl-2020-322161.
    [7]
    WANG HM, TONG JJ, XU X, et al. Reversibility of acute-on-chronic liver failure syndrome in hepatitis B virus-infected patients with and without prior decompensation[J]. J Viral Hepat, 2022, 29( 10): 890- 898. DOI: 10.1111/jvh.13732.
    [8]
    LIN X, HUANG X, WANG L, et al. Prognostic value of acute-on-chronic liver failure(ACLF) score in critically ill patients with cirrhosis and ACLF[J]. Med Sci Monit, 2020, 26: e926574. DOI: 10.12659/msm.926574.
    [9]
    MAIWALL R, PASUPULETI SSR, CHOUDHURY A, et al. AARC score determines outcomes in patients with alcohol-associated hepatitis: A multinational study[J]. Hepatol Int, 2023, 17( 3): 662- 675. DOI: 10.1007/s12072-022-10463-z.
    [10]
    MOREAU R, JALAN R, GINES P, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis[J]. Gastroenterology, 2013, 144( 7): 1426- 1437, 1437.e1-e 9. DOI: 10.1053/j.gastro.2013.02.042.
    [11]
    SY E, RONCO JJ, SEARLE R, et al. Prognostication of critically ill patients with acute-on-chronic liver failure using the Chronic Liver Failure-Sequential Organ Failure Assessment: A Canadian retrospective study[J]. J Crit Care, 2016, 36: 234- 239. DOI: 10.1016/j.jcrc.2016.08.003.
    [12]
    MAIPANG K, POTRANUN P, CHAINUVATI S, et al. Validation of the prognostic models in acute-on-chronic liver failure precipitated by hepatic and extrahepatic insults[J]. PLoS One, 2019, 14( 7): e0219516. DOI: 10.1371/journal.pone.0219516.
    [13]
    HERNAEZ R, SOLÀ E, MOREAU R, et al. Acute-on-chronic liver failure: An update[J]. Gut, 2017, 66( 3): 541- 553. DOI: 10.1136/gutjnl-2016-312670.
    [14]
    GUSTOT T, FERNANDEZ J, GARCIA E, et al. Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis[J]. Hepatology, 2015, 62( 1): 243- 252. DOI: 10.1002/hep.27849.
    [15]
    DHIMAN RK, AGRAWAL S, GUPTA T, et al. Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome[J]. World J Gastroenterol, 2014, 20( 40): 14934- 14941. DOI: 10.3748/wjg.v20.i40.14934.
    [16]
    MACDONALD S, ANDREOLA F, BACHTIGER P, et al. Cell death markers in patients with cirrhosis and acute decompensation[J]. Hepatology, 2018, 67( 3): 989- 1002. DOI: 10.1002/hep.29581.
    [17]
    BAJAJ JS, REDDY KR, O’LEARY JG, et al. Serum levels of metabolites produced by intestinal microbes and lipid moieties independently associated with acute-on-chronic liver failure and death in patients with cirrhosis[J]. Gastroenterology, 2020, 159( 5): 1715- 1730.e 12. DOI: 10.1053/j.gastro.2020.07.019.
    [18]
    CLÀRIA J, STAUBER RE, COENRAAD MJ, et al. Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure[J]. Hepatology, 2016, 64( 4): 1249- 1264. DOI: 10.1002/hep.28740.
    [19]
    ZACCHERINI G, AGUILAR F, CARACENI P, et al. Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF[J]. J Hepatol, 2021, 74( 5): 1117- 1131. DOI: 10.1016/j.jhep.2020.11.035.
    [20]
    BAJAJ JS, O’LEARY JG, REDDY KR, et al. Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures[J]. Hepatology, 2014, 60( 1): 250- 256. DOI: 10.1002/hep.27077.
    [21]
    LI F, THULUVATH P. EASL-CLIF criteria perform better than NACSELD to diagnose and prognosticate ACLF[J]. J Hepatol, 2021, 75( 5): 1096- 1103. DOI: 10.1016/j.jhep.2021.05.033.
    [22]
    CAO ZJ, LIU YH, CAI MH, et al. The use of NACSELD and EASL-CLIF classification systems of ACLF in the prediction of prognosis in hospitalized patients with cirrhosis[J]. Am J Gastroenterol, 2020, 115( 12): 2026- 2035. DOI: 10.14309/ajg.0000000000000771.
    [23]
    O’LEARY JG, REDDY KR, GARCIA-TSAO G, et al. NACSELD acute-on-chronic liver failure(NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis[J]. Hepatology, 2018, 67( 6): 2367- 2374. DOI: 10.1002/hep.29773.
    [24]
    WONG F, PIANO S, SINGH V, et al. Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure[J]. J Hepatol, 2021, 74( 2): 330- 339. DOI: 10.1016/j.jhep.2020.07.046.
    [25]
    ZANETTO A, PELIZZARO F, CAMPELLO E, et al. Severity of systemic inflammation is the main predictor of ACLF and bleeding in individuals with acutely decompensated cirrhosis[J]. J Hepatol, 2023, 78( 2): 301- 311. DOI: 10.1016/j.jhep.2022.09.005.
    [26]
    BELLI LS, DUVOUX C, ARTZNER T, et al. Liver transplantation for patients with acute-on-chronic liver failure(ACLF) in Europe: Results of the ELITA/EF-CLIF collaborative study(ECLIS)[J]. J Hepatol, 2021, 75( 3): 610- 622. DOI: 10.1016/j.jhep.2021.03.030.
    [27]
    WU TZ, LI J, SHAO L, et al. Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure[J]. Gut, 2018, 67( 12): 2181- 2191. DOI: 10.1136/gutjnl-2017-314641.
    [28]
    TIAN XL, WU SL, WANG B, et al. Value of the COSSH-ACLFs model in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure[J]. J Clin Hepatol, 2020, 36( 6): 1258- 1262. DOI: 10.3969/j.issn.1001-5256.2020.06.014.

    田小利, 吴松林, 王波, 等. COSSH-ACLFs评分模型对HBV相关慢加急性肝衰竭患者短期预后的预测价值[J]. 临床肝胆病杂志, 2020, 36( 6): 1258- 1262. DOI: 10.3969/j.issn.1001-5256.2020.06.014.
    [29]
    SHEN ZM, CHEN WJ, LIU YC, et al. Predictive value of COSSH-ACLFⅡ score for short-term prognosis in patients with acute-on-chronic liver failure[J]. Chin Hepatol, 2023, 28( 1): 41- 45. DOI: 10.14000/j.cnki.issn.1008-1704.2023.01.029.

    沈周明, 陈伟杰, 刘一村, 等. COSSH-ACLFⅡ评分对慢加急性肝衰竭患者短期预后的预测价值[J]. 肝脏, 2023, 28( 1): 41- 45. DOI: 10.14000/j.cnki.issn.1008-1704.2023.01.029.
    [30]
    LIU WS, SHEN LJ, TIAN H, et al. ABC prognostic classification and MELD 3.0 and COSSH-ACLF Ⅱ prognostic evaluation in acute-on-chronic liver failure[J]. Chin J Hepatol, 2022, 30( 9): 976- 980. DOI: 10.3760/cma.j.cn501113-20220308-00103.

    刘婉姝, 申力军, 田华, 等. 慢加急性肝衰竭ABC分型的预后及MELD 3.0和COSSH-ACLF Ⅱ对预后评估[J]. 中华肝脏病杂志, 2022, 30( 9): 976- 980. DOI: 10.3760/cma.j.cn501113-20220308-00103.
    [31]
    JALAN R, YURDAYDIN C, BAJAJ JS, et al. Toward an improved definition of acute-on-chronic liver failure[J]. Gastroenterology, 2014, 147( 1): 4- 10. DOI: 10.1053/j.gastro.2014.05.005.
    [32]
    BERNAL W, JALAN R, QUAGLIA A, et al. Acute-on-chronic liver failure[J]. Lancet, 2015, 386( 10003): 1576- 1587. DOI: 10.1016/S0140-6736(15)00309-8.
    [33]
    Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure(2018)[J]. J Clin Hepatol, 2019, 35( 1): 38- 44. DOI: 10.3969/j.issn.1001-5256.2019.01.007.

    中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2018年版)[J]. 临床肝胆病杂志, 2019, 35( 1): 38- 44. DOI: 10.3969/j.issn.1001-5256.2019.01.007.
    [34]
    TREBICKA J, FERNANDEZ J, PAPP M, et al. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology[J]. J Hepatol, 2020, 73( 4): 842- 854. DOI: 10.1016/j.jhep.2020.06.013.
    [35]
    XU MM, KONG M, CAO YY, et al. A new perspective on acute-on-chronic liver failure based on clinical outcome of dynamic classification criteria[J]. Chin J Hepatol, 2020, 28( 4): 319- 325. DOI: 10.3760/cma.j.cn501113-0309-00099.

    徐曼曼, 孔明, 曹影影, 等. 慢加急性肝衰竭分型新视点: 基于临床转归的动态分型新标准[J]. 中华肝脏病杂志, 2020, 28( 4): 319- 325. DOI: 10.3760/cma.j.cn501113-0309-00099.
    [36]
    CHEN Y. Highlight of a new clinical classification of acute-on-chronic liver failure[J]. J Pract Hepatol, 2020, 23( 4): 457- 458. DOI: 10.3969/j.issn.1672-5069.2020.04.001.

    陈煜. 再论慢加急性肝衰竭新的临床分型及临床意义[J]. 实用肝脏病杂志, 2020, 23( 4): 457- 458. DOI: 10.3969/j.issn.1672-5069.2020.04.001.
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