中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 10
Oct.  2023
Turn off MathJax
Article Contents

Clinical features of bacterial liver abscess in the context of coronavirus disease 2019 in Changchun, China

DOI: 10.3969/j.issn.1001-5256.2023.10.017
More Information
  • Corresponding author: WEN Xiaoyu, xywen@jlu.edu.cn (ORCID: 0000-0003-2109-1557)
  • Received Date: 2022-12-22
  • Published Date: 2023-10-30
  •   Objective  To investigate the clinical and epidemiological features of patients with bacterial liver abscess during the outbreak of coronavirus disease 2019 (COVID-19) in Changchun, China.  Methods  A retrospective analysis was performed for 37 411 patients who were discharged from The First Hospital of Jilin University from March 1 to June 30 in 2022, and finally 135 patients with bacterial liver abscess were included for analysis. Related clinical data were collected to summarize their clinical features, and these patients were compared with the patients with bacterial liver abscess in 2019-2021 in terms of disease onset and pathogen. The Kruskal-Wallis H test was used for comparison of continuous data between multiple groups, and the chi-square test was used for comparison of categorical data between multiple groups.  Results  The patients with bacterial liver abscess accounted for 0.36% of the patients admitted to our hospital during the same period of time, which showed varying degrees of increase compared with the previous years (χ2=32.081, P<0.001). The 135 patients with bacterial liver abscess had a mean hospital stay of 11 (6-18) days, which was longer than that in the previous years (H=9.223, P=0.026). The patients with bacterial liver abscess had higher levels of white blood cell count and C-reactive protein (CRP) than the previous years (H=14.150 and 8.736, P=0.003 and 0.033). Among the 135 patients, 69 (51.11%) received blood culture, and the results showed sterile growth (59.42%), Klebsiella pneumoniae (30.43%), Escherichia coli (4.35%), Bacteroides fragilis (1.45%), Enterococcus faecium (1.45%), Staphylococcus epidermidis (1.45%), and Klebsiella oxytoca (1.45%). Among the 135 patients, 90 (66.67%) received pus culture, and the results showed Klebsiella pneumoniae (72.22%), sterile growth (14.44%), Escherichia coli (4.44%), Enterococcus faecium (2.22%), Pseudomonas aeruginosa (2.22%), Acinetobacter baumannii (1.11%), Klebsiella aerogenes (1.11%), Klebsiella oxytoca (1.11%), and Enterococcus casseliflavus (1.11%). Of all 135 patients, 127 (94.07%) were improved and cured after anti-infective therapy and ultrasound-guided abscess puncture and drainage, and 3 patients (2.22%) died during hospitalization.  Conclusion  During the outbreak of COVID-19 in Changchun, there are increases in the number of patients with liver abscess in our hospital, the length of hospital stay, and the levels of white blood cell count and CRP, with Klebsiella pneumoniae as the main pathogen, and most patients are improved after treatment.

     

  • loading
  • [1]
    SI HL, WEI JF, MA L, et al. Clinical features of Klebsiella pneumoniae liver abscess[J]. J Medical Forum, 2021, 42( 15): 44- 48.

    司鸿亮, 魏君锋, 马力, 等. 肺炎克雷伯菌肝脓肿46例的临床特征分析[J]. 医药论坛杂志, 2021, 42( 15): 44- 48.
    [2]
    YIN D, JI C, ZHANG S, et al. Clinical characteristics and management of 1572 patients with pyogenic liver abscess: A 12-year retrospective study[J]. Liver Int, 2021, 41( 4): 810- 818. DOI: 10.1111/liv.14760.
    [3]
    PAN JX, ZHOU QW, ZHENG WP. Clinical characteristics of diabetic and non-diabetic patients with pyogenic liver abscess[J]. Guide China Med, 2021, 19( 35): 13- 15.

    潘金兴, 周庆伟, 郑炜平. 糖尿病与非糖尿病患者并细菌性肝脓肿的临床特征[J]. 中国医药指南, 2021, 19( 35): 13- 15.
    [4]
    OH JH, KANG D, KANG W, et al. Proton pump inhibitor use increases pyogenic liver abscess risk: a nationwide cohort study[J]. J Neurogastroenterol Motil, 2021, 27( 4): 555- 564. DOI: 10.5056/jnm20221.
    [5]
    LIU Y, LI Z, LIU A, et al. Early percutaneous catheter drainage in protecting against prolonged fever among patients with pyogenic liver abscess: a retrospective cohort study[J]. Ann Med, 2022, 54( 1): 2269- 2277. DOI: 10.1080/07853890.2022.2110612.
    [6]
    JIANG HS, DENG MH, LI JY, et al. Analysis of clinical characteristics and risk factors of 137 patients with pyogenic liver abscess[J]. Youjiang Med J, 2023, 51( 1): 36- 41. DOI: 10.3969/j.issn.1003-1383.2023.01.006.

    蒋红双, 邓敏华, 李佳颖, 等. 137例细菌性肝脓肿患者的临床特征及危险因素分析[J]. 右江医学, 2023, 51( 1): 36- 41. DOI: 10.3969/j.issn.1003-1383.2023.01.006.
    [7]
    YU HX, LIN GS, ZHANG JF, et al. Clinical characteristics of 606 patients with community-acquired pyogenic liver abscess: a six-year research in Yantai[J]. Infect Drug Resist, 2022, 15: 7067- 7075. DOI: 10.2147/IDR.S372360.
    [8]
    YU J, MA J, WANG H, et al. Clinical comparison of febrile and afebrile patients with pyogenic liver abscess: A two-centre retrospective study[J]. Saudi J Gastroenterol, 2021, 27( 6): 370- 375. DOI: 10.4103/sjg.sjg_17_21.
    [9]
    WANG F, YU J, CHEN W, et al. Clinical characteristics of diabetes complicated by bacterial liver abscess and nondiabetes-associated liver abscess[J]. Dis Markers, 2022, 2022: 7512736. DOI: 10.1155/2022/7512736.
    [10]
    LIN XY, ZHU YY, LAI RM, et al. Clinical and pathogenic characteristics of bacterial liver abscess of biliary origin[J]. J Fujian Med Univ, 2020, 54( 6): 420- 424. DOI: 10.3969/j.issn.1672-4194.2020.06.012.

    林晓宇, 朱月永, 赖瑞敏, 等. 胆源性细菌性肝脓肿临床及病原学特征[J]. 福建医科大学学报, 2020, 54( 6): 420- 424. DOI: 10.3969/j.issn.1672-4194.2020.06.012.
    [11]
    ZHU Z, ZHANG B, WANG Y, et al. A wide clinical spectrum of pulmonary affection in subjects with community-acquired Klebsiella pneumoniae liver abscess(CA-KPLA)[J]. J Infect Chemother, 2023, 29( 1): 48- 54. DOI: 10.1016/j.jiac.2022.09.011.
    [12]
    LI F, ZHANG H, XU Y, et al. Clinical and CT comparative study of invasive and non-invasive Klebsiella pneumoniae liver abscesses[J]. Clin Radiol, 2023, 78( 1): 40- 46. DOI: 10.1016/j.crad.2022.08.145.
    [13]
    WANG Y, LI WK, SU JY, et al. Clinical characteristics of pyogenic liver abscesses and risk factors for admission to intensive care unit[J]. J Clin Exp Med, 2022, 21( 20): 2233- 2238. DOI: 10.3969/j.issn.1671-4695.2022.20.029.

    王芸, 李文坤, 苏珈仪, 等. 细菌性肝脓肿临床特征及其入住重症监护室危险因素分析[J]. 临床和实验医学杂志, 2022, 21( 20): 2233- 2238. DOI: 10.3969/j.issn.1671-4695.2022.20.029.
    [14]
    SHINMOTO K, OHBE H, NAKAJIMA M, et al. Outcomes after early versus delayed antibiotic treatment of liver abscess in Japan: A nationwide retrospective cohort study[J]. J Infect Chemother, 2023, 29( 1): 1- 6. DOI: 10.1016/j.jiac.2022.08.029.
    [15]
    GUO JJ, WANG HZ, LI J, et al. Analysis on distribution of bacterial etiology and drug resistance of 39 cases with liver abscess[J/CD]. Chin J Exp Clin Infect Dis(Electronic Edition), 2015, 9( 1): 69- 72. DOI: 10.3877/cma.j.issn.1674-1358.2015.01.018.

    郭晶晶, 王慧珠, 李娟, 等. 39例细菌性肝脓肿患者的病原学分布及耐药性分析[J/CD]. 中华实验和临床感染病杂志(电子版), 2015, 9( 1): 69- 72. DOI: 10.3877/cma.j.issn.1674-1358.2015.01.018.
    [16]
    CAI YL. Analysis of clinical characteristics of 198 bacterial liver abscess cases[D]. Fuzhou: Fujian Medical University, 2021.

    蔡跃龙. 198例细菌性肝脓肿的临床特点分析[D]. 福州: 福建医科大学, 2021.
    [17]
    DING R, XIE W, LIU LG, et al. Clinical features of Klebsiella pneumoniae liver abscess and influencing factors for prognosis[J]. J Clin Hepatol, 2022, 38( 7): 1584- 1589. DOI: 10.3969/j.issn.1001-5256.2022.07.023.

    丁蕊, 谢雯, 刘丽改, 等. 肺炎克雷伯菌肝脓肿的临床特征及预后影响因素分析[J]. 临床肝胆病杂志, 2022, 38( 7): 1584- 1589. DOI: 10.3969/j.issn.1001-5256.2022.07.023.
    [18]
    HUANG H, CHEN J, DANG H, et al. Comparing outcomes between culture-positive and culture-negative septic shock in a PICU: A retrospective cohort study[J]. Front Pediatr, 2022, 10: 1001565. DOI: 10.3389/fped.2022.1001565.
    [19]
    MYEONG JH, KYOUNG DS, PARK MA, et al. Anaerobe coverage is important for the prognosis of pyogenic liver abscess: A population-based study in Korea[J]. J Infect Public Health, 2022, 15( 4): 425- 432. DOI: 10.1016/j.jiph.2022.03.003.
    [20]
    LI S, LUO J, WANG Z, et al. Efficacy and prognosis of ultrasound-guided percutaneous catheter drainage in patients with liver abscess complicated with septic shock[J]. Comput Math Methods Med, 2022, 2022: 4688356. DOI: 10.1155/2022/4688356.
    [21]
    ZHANG J, WANG T, FANG Y, et al. Clinical significance of serum albumin/globulin ratio in patients with pyogenic liver abscess[J]. Front Surg, 2021, 8: 677799. DOI: 10.3389/fsurg.2021.677799.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(2)

    Article Metrics

    Article views (171) PDF downloads(15) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return