中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 10
Oct.  2023
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Article Contents

Role of heat shock protein 90 in hepatitis B virus replication

DOI: 10.3969/j.issn.1001-5256.2023.10.023
Research funding:

General Project of National Natural Science Foundation of China (32171277)

More Information
  • Corresponding author: ZHANG Mei, xiangrui20001009@sina.com.cn (ORCID: 0000-0002-3293-0777); XUAN Shiying, xuansydxy@163.com (ORCID: 0000-0002-9849-1877)
  • Received Date: 2023-01-17
  • Published Date: 2023-10-30
  • Hepatitis B virus (HBV) has the characteristics of wide transmission, a high chronic infection rate, and a low cure rate, and improving the cure rate of HBV may help to improve the long-term prognosis of patients. Heat shock protein 90 (Hsp90) is a chaperone protein widely present in organisms. In recent years, more and more studies have shown that Hsp90 is associated with HBV infection and plays an important role in HBV replication. It can not only interact with specific proteins of the virus to promote its replication, but also interact with the host’s own proteins to perform its function. This article reviews the role of Hsp90 in HBV replication in recent studies, so as to provide new theoretical guidance and directions for the development of new anti-HBV drugs targeting Hsp90 and the prevention and treatment of HBV infection in the future.

     

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