中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 10
Oct.  2023
Turn off MathJax
Article Contents

Research advances in hepatitis E virus infection in pregnancy

DOI: 10.3969/j.issn.1001-5256.2023.10.024
More Information
  • Corresponding author: HUANG Yuan, huangy9815@163.com (ORCID: 0000-0002-5534-4527)
  • Received Date: 2023-01-31
  • Published Date: 2023-10-30
  • Previous studies have shown that hepatitis E virus (HEV) infection in pregnancy can cause liver failure and adverse pregnancy outcomes such as miscarriage, stillbirth, and vertical transmission, especially in countries where HEV genotypes 1 and 2 are prevalent. In recent years, HEV infection in China is sporadic and is mainly caused by HEV genotype 4, and although studies have shown that most pregnant women with HEV infection in China have no signfinicant clinical symptoms, there is still a high incidence rate of adverse pregnancy outcomes. This article reviews the recent studies on HEV infection in pregnancy, including the advances in pathogenesis, epidemiology, prognosis, mechanism of severe exacerbation, treatment, and prognosis, and puts forward recommendations for the screening and evaluation of HEV infection in pregnancy.

     

  • loading
  • [1]
    SMITH DB, IZOPET J, NICOT F, et al. Update: proposed reference sequences for subtypes of hepatitis E virus(species Orthohepevirus A)[J]. J Gen Virol, 2020, 101( 7): 692- 698. DOI: 10.1099/jgv.0.001435.
    [2]
    LHOMME S, LEGRAND-ABRAVANEL F, KAMAR N, et al. Screening, diagnosis and risks associated with hepatitis E virus infection[J]. Expert Rev Anti Infect Ther, 2019, 17( 6): 403- 418. DOI: 10.1080/14787210.2019.1613889.
    [3]
    BES M, COSTAFREDA MI, RIVEIRO-BARCIELA M, et al. Effect of hepatitis E virus RNA universal blood donor screening, Catalonia, Spain, 2017-2020[J]. Emerg Infect Dis, 2022, 28( 1): 157- 165. DOI: 10.3201/eid2801.211466.
    [4]
    CHILAKA VN, KONJE JC. Viral hepatitis in pregnancy[J]. Eur J Obstet Gynecol Reprod Biol, 2021, 256: 287- 296. DOI: 10.1016/j.ejogrb.2020.11.052.
    [5]
    QASHQARI FS. Seroprevalence of hepatitis E virus infection in Middle Eastern Countries: A systematic review and Meta-analysis[J]. Medicina(Kaunas), 2022, 58( 7): 905. DOI: 10.3390/medicina58070905.
    [6]
    BIGNA JJ, MODIYINJI AF, NANSSEU JR, et al. Burden of hepatitis E virus infection in pregnancy and maternofoetal outcomes: a systematic review and meta-analysis[J]. BMC Pregnancy Childbirth, 2020, 20( 1): 426. DOI: 10.1186/s12884-020-03116-2.
    [7]
    AHMAD T, HUI J, MUSA TH, et al. Seroprevalence of hepatitis E virus infection in pregnant women: a systematic review and meta-analysis[J]. Ann Saudi Med, 2020, 40( 2): 136- 146. DOI: 10.5144/0256-4947.2020.136.
    [8]
    SRIDHAR S, LO SK, XING F, et al. Clinical characteristics and molecular epidemiology of hepatitis E in Shenzhen, China: a shift toward foodborne transmission of hepatitis E virus infection[J]. Emerg Microbes Infect, 2017, 6( 12): e115. DOI: 10.1038/emi.2017.107.
    [9]
    WANG L, LIU L, WEI Y, et al. Clinical and virological profiling of sporadic hepatitis E virus infection in China[J]. J Infect, 2016, 73( 3): 271- 279. DOI: 10.1016/j.jinf.2016.06.005.
    [10]
    YUE N, WANG Q, ZHENG M, et al. Prevalence of hepatitis E virus infection among people and swine in mainland China: A systematic review and meta-analysis[J]. Zoonoses Public Health, 2019, 66( 3): 265- 275. DOI: 10.1111/zph.12555.
    [11]
    BO QN, WANG SY, LI ZF, et al. Serological and clinical characteristics of hepatitis E virus infection in pregnant women in Qinhuangdao[J]. Chin Hepatol, 2019, 24( 10): 1150- 1154. DOI: 10.3969/j.issn.1008-1704.2019.10.019.

    卜秋宁, 王术艺, 李宗锋, 等. 秦皇岛地区孕妇戊型肝炎病毒感染的血清学及临床特征[J]. 肝脏, 2019, 24( 10): 1150- 1154. DOI: 10.3969/j.issn.1008-1704.2019.10.019.
    [12]
    BERGLØV A, HALLAGER S, WEIS N. Hepatitis E during pregnancy: Maternal and foetal case-fatality rates and adverse outcomes-A systematic review[J]. J Viral Hepat, 2019, 26( 11): 1240- 1248. DOI: 10.1111/jvh.13129.
    [13]
    BHATNAGAR N, PRAKASH S, RAMAKRISHNA V, et al. Molecular characterisation of hepatitis E virus isolates from north India[J]. Indian J Med Microbiol, 2022, 40( 1): 91- 95. DOI: 10.1016/j.ijmmb.2021.09.004.
    [14]
    SAYED IM, ABDELWAHAB SF. Is hepatitis E virus a neglected or emerging pathogen in Egypt?[J]. Pathogens, 2022, 11( 11): 1337. DOI: 10.3390/pathogens11111337.
    [15]
    OKWARA VC, MBACHU II, NDUBUBA VI, et al. Seroprevalence, associated factors, and fetomaternal outcome in pregnant women that tested positive to hepatitis E antibodies in nigeria[J]. Obstet Gynecol Int, 2021, 2021: 9341974. DOI: 10.1155/2021/9341974.
    [16]
    VELAVAN TP, PALLERLA SR, JOHNE R, et al. Hepatitis E: an update on one health and clinical medicine[J]. Liver Int, 2021, 41( 7): 1462- 1473. DOI: 10.1111/liv.14912.
    [17]
    BOUTHRY E, BENACHI A, VIVANTI AJ, et al. Autochthonous hepatitis E during pregnancy, France[J]. Emerg Infect Dis, 2018, 24( 8): 1586- 1587. DOI: 10.3201/eid2408.180105.
    [18]
    CHARRE C, RAMIÈRE C, DUMORTIER J, et al. Chronic genotype 3 hepatitis E in pregnant woman receiving infliximab and azathioprine[J]. Emerg Infect Dis, 2018, 24( 5): 941- 943. DOI: 10.3201/eid2405.171845.
    [19]
    HUY PX, CHUNG DT, LINH DT, et al. Low prevalence of HEV infection and No associated risk of HEV transmission from mother to child among pregnant women in vietnam[J]. Pathogens, 2021, 10( 10): 1340. DOI: 10.3390/pathogens10101340.
    [20]
    LI M, BU Q, GONG W, et al. Hepatitis E virus infection and its associated adverse feto-maternal outcomes among pregnant women in Qinhuangdao, China[J]. J Matern Fetal Neonatal Med, 2020, 33( 21): 3647- 3651. DOI: 10.1080/14767058.2019.1582630.
    [21]
    ZHANG F, WANG J, CHENG J, et al. Clinical features of sporadic hepatitis E virus infection in pregnant women in Shanghai, China[J]. J Infect, 2022, 84( 1): 64- 70. DOI: 10.1016/j.jinf.2021.11.004.
    [22]
    YADAV KK, KENNEY SP. Hepatitis E virus immunopathogenesis[J]. Pathogens, 2021, 10( 9): 1180. DOI: 10.3390/pathogens10091180.
    [23]
    WU J, GUO Y, LU X, et al. Th1/Th2 cells and associated cytokines in acute hepatitis E and related acute liver failure[J]. J Immunol Res, 2020, 2020: 6027361. DOI: 10.1155/2020/6027361.
    [24]
    LIN S, ZHANG YJ. Advances in hepatitis E virus biology and pathogenesis[J]. Viruses, 2021, 13( 2). DOI: 10.3390/v13020267.
    [25]
    SHATA MTM, HETTA HF, SHARMA Y, et al. Viral hepatitis in pregnancy[J]. J Viral Hepat, 2022, 29( 10): 844- 861. DOI: 10.1111/jvh.13725.
    [26]
    KHUROO MS. Hepatitis E and pregnancy: an unholy alliance unmasked from Kashmir, India[J]. Viruses, 2021, 13( 7): 1329. DOI: 10.3390/v13071329.
    [27]
    SAXENA A, SIDDIQUI H, SEVAK JK, et al. IL-7 induced CD4+ memory stem T cell-derived pro-inflammatory cytokine storm plays a role in hepatitis E induced pathogenesis in pregnant women[C]. AASLD, 2022: 1014.
    [28]
    HORVATITS T, PISCHKE S. HEV in pregnancy: Understanding the crucial role of steroid hormones[J]. Liver Int, 2019, 39( 4): 621- 622. DOI: 10.1111/liv.13942.
    [29]
    SINGH S, DAGA MK, KUMAR A, et al. Role of oestrogen and its receptors in HEV-associated feto-maternal outcomes[J]. Liver Int, 2019, 39( 4): 633- 639. DOI: 10.1111/liv.13928.
    [30]
    KUMAR A, SHARMA S, KAR P, et al. Impact of maternal nutrition in hepatitis E infection in pregnancy[J]. Arch Gynecol Obstet, 2017, 296( 5): 885- 895. DOI: 10.1007/s00404-017-4501-y.
    [31]
    Chinese Society of Hepatology, Chinese Medical Association. Consensus on prevention and treatment of hepatitis E[J]. Chin J Hepatol, 2022, 30( 8): 820- 831. DOI: 10.3760/cma.j.cn501113-20220729-00401.

    中华医学会肝病学分会. 戊型肝炎防治共识[J]. 中华肝脏病杂志, 2022, 30( 8): 820- 831. DOI: 10.3760/cma.j.cn501113-20220729-00401.
    [32]
    WU J, BORTOLANZA M, ZHAI G, et al. Gut microbiota dysbiosis associated with plasma levels of Interferon-γ and viral load in patients with acute hepatitis E infection[J]. J Med Virol, 2022, 94( 2): 692- 702. DOI: 10.1002/jmv.27356.
    [33]
    WU J, XU Y, CUI Y, et al. Dynamic changes of serum metabolites associated with infection and severity of patients with acute hepatitis E infection[J]. J Med Virol, 2022, 94( 6): 2714- 2726. DOI: 10.1002/jmv.27669.
    [34]
    WU J, GUO N, ZHANG X, et al. HEV-LFS: A novel scoring model for patients with hepatitis E virus-related liver failure[J]. J Viral Hepat, 2019, 26( 11): 1334- 1343. DOI: 10.1111/jvh.13174.
    [35]
    WU J, SHI C, SHENG X, et al. Prognostic nomogram for patients with hepatitis E virus-related acute liver failure: a multicenter study in China[J]. J Clin Transl Hepatol, 2021, 9( 6): 828- 837. DOI: 10.14218/JCTH.2020.00117.
    [36]
    RIVERO-JUAREZ A, LOPEZ-LOPEZ P, PINEDA JA, et al. Limited value of single sampling for igm antibody determination as a diagnostic approach for acute hepatitis E virus infection[J]. Microbiol Spectr, 2021, 9( 1): e0038221. DOI: 10.1128/Spectrum.00382-21.
    [37]
    AL-SADEQ DW, MAJDALAWIEH AF, MESLEH AG, et al. Laboratory challenges in the diagnosis of hepatitis E virus[J]. J Med Microbiol, 2018, 67( 4): 466- 480. DOI: 10.1099/jmm.0.000706.
    [38]
    RIVEIRO-BARCIELA M, RANDO-SEGURA A, BARREIRA-DÍAZ A, et al. Unexpected long-lasting anti-HEV IgM positivity: Is HEV antigen a better serological marker for hepatitis E infection diagnosis?[J]. J Viral Hepat, 2020, 27( 7): 747- 753. DOI: 10.1111/jvh.13285.
    [39]
    MARION O, CAPELLI N, LHOMME S, et al. Hepatitis E virus genotype 3 and capsid protein in the blood and urine of immunocompromised patients[J]. J Infect, 2019, 78( 3): 232- 240. DOI: 10.1016/j.jinf.2019.01.004.
    [40]
    YING D, HE Q, TIAN W, et al. Urine is a viral antigen reservoir in hepatitis E virus infection[J]. Hepatology, 2023, 77( 5): 1722- 1734. DOI: 10.1002/hep.32745.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)

    Article Metrics

    Article views (171) PDF downloads(49) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return