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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 10
Oct.  2023
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Article Contents

Advances in the protective mechanism and clinical implications of autophagy in liver failure

DOI: 10.3969/j.issn.1001-5256.2023.10.030
Research funding:

Natural Science Foundation of Hebei Province (H2020206036);

Key Research and Development Project of Hebei Province (21377756D)

More Information
  • Corresponding author: WANG Yadong, wangyadong8060@126.com (ORCID: 0000-0003-0140-0674)
  • Received Date: 2023-02-08
  • Published Date: 2023-10-30
  • ‍Liver failure is a serious clinical syndrome of liver disease with critical condition and high mortality, and besides liver transplantation, there is still a lack of satisfactory radical treatment methods. The pathogenesis of liver failure is complex and remains unclear, involving a variety of factors that affect the balance of hepatocyte necrosis and regeneration. This article summarizes autophagy as the key pathway for maintaining cell homeostasis and points out that autophagy plays an important protective role in the pathogenesis of liver failure by regulating NLRP3 inflammasome activation, reducing oxidative stress, and inhibiting cell apoptosis. Meanwhile, it is believed that the molecular signaling pathways targeting autophagy, such as exosomes and peroxisome proliferator-activated receptor α, participate in antagonizing the development and progression of liver failure and will become important ideas and directions for molecular targeted therapies for liver failure.

     

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