吉林大学第一医院肝胆胰内科 张明媛 摘译
本文首次发表于[Int J Obes (Lond). 2012 Apr 24. doi: 10.1038/ijo.2012.63. ]
Association between obesity, hypertriglyceridemia and low hepatitis B viral load
Abstract
BACKGROUND AND AIMS: This study aimed to investigate the metabolic risk factors of high hepatitis B viral load.
METHODS: Large-scale, community-based cross-sectional study. A total of 3587 hepatitis B virus (HBV)-infected participants without liver cirrhosis at study entry were investigated. High HBV viral load was defined as a serum level 104 copies per ml for hepatitis B e antigen (HBeAg) seronegatives or 108 copies per ml for HBeAg seropositives.
RESULTS: Among HBeAg seropositives (n=545), high HBV viral load was reversely associated with extreme obesity, (odds ratio (OR), 0.30; 95% confidence interval (CI), 0.13–0.68; P=0.004) or central obesity (OR, 0.53; 95% CI, 0.34–0.82; P=0.004) after adjustment for gender, hypertriglyceridemian., hyperuricemia and history of hypertension. High HBV viral load remained significantly inversely associated with extreme obesity (OR, 0.17; 95% CI, 0.05–0.63; P=0.008) and central obesity (OR, 0.44; 95% CI, 0.25–0.78; P=0.005) in male HBeAg-seropositive participants in stratification analyses by gender. Among HBeAg seronegatives (n=3042),however, high HBV viral load was inversely associated with hypertriglyceridemia (OR, 0.74; 95% CI, 0.61–0.89, P=0.002) after adjustment for age, gender, high serum alanine aminotransferase level, and extreme obesity or central obesity. High HBV viral load was still inversely associated with hypertriglyceridemia in both female (OR, 0.70; 95% CI, 0.50–0.97; P=0.041) and male (OR, 0.75; 95% CI, 0.60–0.94; P=0.011) HBeAg-seronegative participants.
CONCLUSIONS: Extreme obesity and central obesity were associated with a low prevalence of high HBV viral load in HBeAg seropositives, especially in men; while hypertriglyceridemia was associated with a low prevalence of high viral load in HBeAg seronegatives in both women and men.
