多结节肝癌病人常常在肝部分切除术后会有早期复发。我们回溯性研究观察肝部分切除术后1年内寡结节肝细胞癌(2或3结节)复发率、探讨早期复发的危险因素。研究对象包括102例2009年1月至2009年12月接受切除治疗的2或3 HCCs患者。收集临床病理的数据进行单变量和多变量分析。肝部分切除术后1年内43个病人复发。根据单变量分析,早期复发的危险因素是甲胎蛋白> 200纳克/毫升,微血管的参与和缺乏完整的肿瘤囊被膜；多变量分析提示对早期复发，微血管是一个独立预测因素 (危险比4.02;95% CI,1.42 - -11.39,p = 0.009)。寡结节肝细胞癌患者肝部分切除术后早期复发率高。对于早期复发，微血管的参与是一个独立预测因素。那些肝部分切除术后病人可能考虑比如 TACE 的辅助治疗。
吉林大学第一医院肝胆胰内科 侯捷 摘译
本文首次发表于[ Hepatogastroenterology, 2012, 60(121)]
Early Recurrence after Curative Resection in Oligonodular Hepatocellular Carcinoma
Often patients experience an unexpected early recurrence after hepatectomy for multinodular HCC. We conducted this retrospective study to observe the recurrence rate within 1 year after hepatectomy for oligonodular HCC (2 or 3 nodules) and investigate the risk factors for early recurrence.The study population consisted of 102 patients with 2 or 3 HCCs that received curative resection between January 2009 and December 2009. Clinicopathological data were collected and subjected to univariate and multivariate analysis. Forty-three (42.2%) patients were diagnosed as with recurrence within 1 year after hepatectomy. According to univariate analysis, the risk factors for early recurrence were alpha-fetoprotein (AFP) >200ng/mL, microvascular involvement and lack of complete tumor capsule;microvascular involvement was an independent predictive factor for early recurrence by multivariate analysis (HR, 4.02; 95% CI, 1.42-11.39, p=0.009). There was a high rate of early recurrence for patients with oligonodular HCC (2 or 3 nodules) after hepatectomy. Microvascular involvement was an independent predictive factor for early recurrence, and adjuvant therapy, such as TACE, may be considered for those patients after hepatectomy。
吉林大学第一医院肝胆胰内科 侯捷 摘译
本文首次发表于[ Hepatogastroenterology, 2012, 60(121)]
Early Recurrence after Curative Resection in Oligonodular Hepatocellular Carcinoma
Often patients experience an unexpected early recurrence after hepatectomy for multinodular HCC. We conducted this retrospective study to observe the recurrence rate within 1 year after hepatectomy for oligonodular HCC (2 or 3 nodules) and investigate the risk factors for early recurrence.The study population consisted of 102 patients with 2 or 3 HCCs that received curative resection between January 2009 and December 2009. Clinicopathological data were collected and subjected to univariate and multivariate analysis. Forty-three (42.2%) patients were diagnosed as with recurrence within 1 year after hepatectomy. According to univariate analysis, the risk factors for early recurrence were alpha-fetoprotein (AFP) >200ng/mL, microvascular involvement and lack of complete tumor capsule;microvascular involvement was an independent predictive factor for early recurrence by multivariate analysis (HR, 4.02; 95% CI, 1.42-11.39, p=0.009). There was a high rate of early recurrence for patients with oligonodular HCC (2 or 3 nodules) after hepatectomy. Microvascular involvement was an independent predictive factor for early recurrence, and adjuvant therapy, such as TACE, may be considered for those patients after hepatectomy。
