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基于肠道微生态探讨中医药治疗非酒精性脂肪性肝病的作用机制

杨雪 张旭 仙晋 谭奇纹 于慧娟

引用本文:
Citation:

基于肠道微生态探讨中医药治疗非酒精性脂肪性肝病的作用机制

DOI: 10.12449/JCH240426
基金项目: 

山东中医药大学重点学科:中医治未病学 ;

山东中医药大学附属医院朝阳人才项目 

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:杨雪、张旭负责查找文献,撰写文稿;仙晋、谭奇纹负责文章思路指导;于慧娟负责审阅文稿及最后定稿。
详细信息
    通信作者:

    于慧娟, huijuanyu@163.com (ORCID: 0000-0003-1180-5704)

Mechanism of action of traditional Chinese medicine in treatment of nonalcoholic fatty liver disease based on intestinal microecology

Research funding: 

Key Discipline of Shandong University of Traditional Chinese Medicine: Traditional Chinese Medicine Prevention and Treatment ;

Chaoyang Talent Project of Shandong University of Traditional Chinese Medicine Affiliated Hospital 

More Information
    Corresponding author: YU Huijuan, huijuanyu@163.com (ORCID: 0000-0003-1180-5704)
  • 摘要: 非酒精性脂肪性肝病(NAFLD)是一种与肥胖、胰岛素抵抗和血脂异常相关的多系统疾病,其发病机制较为复杂。肠道菌群失调与NAFLD的发病密切相关,中医药治疗可通过调节肠道菌群及其代谢产物,改善NAFLD患者的实验室指标和临床症状。本文总结了NAFLD与肠道菌群的关系、肠道菌群失调参与NAFLD的发病机制,从肠道菌群角度探讨中医药治疗改善NAFLD的可能等,以期为NAFLD的治疗拓展新的思路。

     

  • 表  1  疾病发展过程中肠道菌群的差异

    Table  1.   Differences in intestinal flora during disease development

    疾病 升高 降低 参考文献
    门水平 科属水平 门水平 科属水平
    单纯性脂肪肝 厚壁菌、变形杆菌、放线菌 脱硫菌 拟杆菌 阿克曼菌、瘤胃球菌科 9
    NASH 厚壁菌门、变形杆菌 普雷沃菌属、毛螺菌科、另枝菌属、肠杆菌科 拟杆菌门(乳酸菌、瘤胃球菌) 双歧杆菌科、双歧杆菌属、拟杆菌属 10-14
    肝硬化 变形菌门、梭菌门 肠杆菌科(属)、肠球菌科(属)、韦荣球菌属、链球菌属、梭菌属、普雷沃菌属 拟杆菌门 拟杆菌属、双歧杆菌属、瘤胃球菌属、粪球菌属 15-19
    肝细胞癌 厚壁菌门 大肠杆菌属、肠球菌属、梭菌属、考拉杆菌属、颤螺菌属、克雷伯杆菌属、嗜血杆菌属、毛螺菌属 拟杆菌门 颤杆菌克属、粪杆菌属、粪球菌属、乳酸杆菌属、双歧杆菌属、经黏液真杆菌属 20-24
    下载: 导出CSV
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  • 收稿日期:  2023-09-02
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