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微球和纳米颗粒在经动脉化疗栓塞治疗肝细胞癌中的应用

张楚悦 史家宁 王明达 吴寒 史立军 杨田

引用本文:
Citation:

微球和纳米颗粒在经动脉化疗栓塞治疗肝细胞癌中的应用

DOI: 10.12449/JCH240428
基金项目: 

国家自然科学基金 (82273074)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:张楚悦、史家宁负责撰写论文;吴寒、王明达、杨田负责修改论文;史立军、杨田负责拟定写作思路,指导撰写文章并最后定稿。张楚悦、史家宁对文本贡献等同,同为第一作者。
详细信息
    通信作者:

    杨田, yangtian6666@hotmail.com (ORCID: 0000-0003-1544-0976)

Advances in the application of microspheres and nanoparticles in transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma

Research funding: 

National Natural Science Foundation of China (82273074)

More Information
  • 摘要: 近年来,经动脉化疗栓塞(TACE)是治疗肝细胞癌(HCC)的常用方法。然而,随着栓塞剂技术的不断发展,微球和纳米颗粒方面的新进展为提高TACE的治疗效果和安全性带来了新的希望。本文综述了微球和纳米颗粒在HCC行TACE中的最新进展和应用。首先,介绍了TACE作为治疗手段的背景,以及微球和纳米颗粒技术的兴起。接着,叙述了TACE中不同类型的微球和纳米颗粒的使用情况,并探讨了理想栓塞剂的特性。文章着重描述了在材料科学和工程领域的进展,以及药物释放微球和纳米颗粒与传统TACE在临床效果方面的对比。另外,对影像学在TACE手术中的重要性进行了讨论,并总结了放射性和磁共振可见的栓塞剂的研究进展。文章从多个角度讨论了TACE治疗的未来发展方向和面临的挑战。指出了微球和纳米颗粒与其他治疗方法结合、个性化和精准医学在TACE中的应用,以及TACE在临床转化应用中的潜在方案。同时,提出了伦理和监管方面的问题需要加以探讨。认为先进微球和纳米颗粒在TACE中具有潜在影响,为HCC治疗模式的创新以及通过TACE改善患者预后提供了理论基础和技术支持。

     

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  • 收稿日期:  2023-07-25
  • 录用日期:  2023-08-10
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