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肝再生在对乙酰氨基酚诱导的肝损伤修复中的作用

莫胤康 范子豪 任锋

引用本文:
Citation:

肝再生在对乙酰氨基酚诱导的肝损伤修复中的作用

DOI: 10.12449/JCH240929
基金项目: 

国家自然科学基金 (81770611);

国家自然科学基金 (82002243);

北京自然科学基金和北京市教委联合资助重点项目 (KZ202010025035);

首都卫生发展科研专项重点攻关项目 (SF2020-1-1151);

北京市科技计划“首都临床诊疗技术研究及示范应用”专项课题 (Z191100006619096);

北京市科技计划“首都临床诊疗技术研究及示范应用”专项课题 (Z191100006619097);

北京市医院管理中心“青苗”计划专项经费资助项目 (QML20201702);

北京市医管局“登峰”人才计划 (DFL20221503);

高层次公共卫生技术人才建设项目 (Subject leaders-02-13);

2023年度北京市自然科学基金-昌平创新联合基金拟资助项目 (L234046)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:莫胤康负责设计论文框架,起草论文;范子豪、莫胤康负责论文修改;任锋负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    任锋, renfeng7512@ccmu.edu.cn (ORCID: 0000-0001-7736-8637)

Role of liver regeneration in the repair of liver injury induced by N-acetyl-p-aminophenol

Research funding: 

National Natural Science Foundation of China (81770611);

National Natural Science Foundation of China (82002243);

Key Projects of the Beijing Municipal Education Commission’s Science and Technology Plan (KZ202010025035);

Special Key Research Project of Capital Health Development Scientific Research (SF2020-1-1151);

Capital Clinical Characteristic Diagnosis and Treatment Technology Research and Transformation Application (Z191100006619096);

Capital Clinical Characteristic Diagnosis and Treatment Technology Research and Transformation Application (Z191100006619097);

Beijing Hospitals Authority Youth Programme (QML20201702);

Talent Cultivation Plan of “Climbing the peak” of Beijing Municipal Hospital Administration (DFL20221503);

High-level Public Health Technical Personnel Construction Project (Subject leaders-02-13);

Proposed Funding Project for the 2023 Beijing Natural Science Foundation Changping Innovation Joint Fund (L234046)

More Information
  • 摘要: 肝再生在对乙酰氨基酚(APAP)诱导的肝损伤后恢复中有着至关重要的作用。APAP过量服用后,通常是肝损伤程度越大,再生的程度就越大,从而导致肝损伤的消退和大多数情况下的自发恢复。然而,严重APAP过量会导致肝再生受损和无法控制的肝损伤,导致无法恢复,甚至死亡。在APAP肝损伤后,肝脏中细胞之间的相互作用对再生反应非常重要。肝再生由多种增殖信号通路共同调控,这些通路涉及激酶、核受体、转录因子、转录共激活因子。严重的APAP过量后会抑制增殖信号通路的激活,导致细胞周期停滞和肝再生受损。虽然肝再生在APAP肝损伤后的修复过程中发挥关键作用,但目前其发挥作用的潜在机制尚不明确。本文就已有的相关研究对肝再生在APAP诱导的肝损伤中的作用进行综述, 为进一步的基础研究提供参考。

     

  • 图  1  APAP诱导肝毒性后肝再生过程的机制图

    Figure  1.  Mechanism diagram of liver regeneration following APAP -hepatotoxicity

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  • 收稿日期:  2023-12-28
  • 录用日期:  2024-04-22
  • 出版日期:  2024-09-25
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