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巨噬细胞在原发性胆汁性胆管炎发生发展中的作用

邓宗柒 邰文琳

引用本文:
Citation:

巨噬细胞在原发性胆汁性胆管炎发生发展中的作用

DOI: 10.12449/JCH240932
基金项目: 

国家自然科学基金 (82060385);

昆明医科大学2024年研究生创新基金 (2024S091)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:邓宗柒负责收集资料及文章撰写;邰文琳负责文章修改及定稿。
详细信息
    通信作者:

    邰文琳, taiwenlin2685@163.com (ORCID: 0000-0002-8278-929X)

Role of macrophages in the development and progression of primary biliary cholangitis

Research funding: 

National Natural Science Foundation of China (82060385);

Innovation Fund for Graduate Students of Kunming Medical University in 2024 (2024S091)

More Information
  • 摘要: 原发性胆汁性胆管炎(PBC)是一种持续的炎症性自身免疫性肝病,以肝内小胆管炎症损伤和胆汁淤积为主要特征。目前,PBC的确切发病机制尚不清楚,但一致认为PBC是多种因素协同作用的结果。而在与PBC相关的免疫和炎症级联反应中,巨噬细胞作为必不可少的免疫细胞出现,积极参与对胆管上皮细胞的损伤。本文介绍了巨噬细胞在PBC中的来源定位及异质性变化,综述了巨噬细胞在PBC发病机制中的潜在作用。

     

  • 图  1  巨噬细胞参与PBC发病和进展的机制图

    Figure  1.  Mechanism diagram of macrophage involvement in the pathogenesis and progression of PBC

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  • 收稿日期:  2024-01-09
  • 录用日期:  2024-03-07
  • 出版日期:  2024-09-25
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