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CD8+T淋巴细胞在非酒精性脂肪性肝炎中的作用

赵一鸣 李开楊 杨梅 赵琦

引用本文:
Citation:

CD8+T淋巴细胞在非酒精性脂肪性肝炎中的作用

DOI: 10.12449/JCH241026
基金项目: 

国家自然科学基金项目 (82160866);

贵州省科技计划项目 (Guizhou Science and Technology base-ZK [2023] General 433);

贵州省卫生健康委科学技术基金资助项目 (gzwkj2023-208);

贵州省高等学校重点实验室 (Guizhou Education Technology [2023]017)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:赵一鸣负责设计论文框架及撰写论文;李开楊负责指导撰写文章并最后定稿;杨梅负责论文修改;赵琦负责指导撰写文章。
详细信息
    通信作者:

    杨梅, 908417289@qq.com (ORCID: 0009-0003-3563-4767)

The role of CD8+ T cells in nonalcoholic steatohepatitis

Research funding: 

National Natural Science Foundation of China (82160866);

Science and Technology Plan Project of Guizhou Province (Guizhou Science and Technology base-ZK [2023] General 433);

Science and Technology Fund of Guizhou Provincial Health Commission (gzwkj2023-208);

Key Laboratory of Higher Education in Guizhou Province (Guizhou Education Technology [2023]017)

More Information
    Corresponding author: YANG Mei, 908417289@qq.com (ORCID: 0009-0003-3563-4767)
  • 摘要: 非酒精性脂肪性肝炎(NASH)是一种与代谢综合征密切相关的肝脏疾病,其发病机制包括胰岛素抵抗、脂质代谢紊乱、炎症反应等方面。本文简述了CD8+T淋巴细胞通过Fas-Fas配体(FasL)信号通路、释放穿孔素和颗粒酶以及分泌肿瘤坏死因子(TNF)α等细胞因子三种途径发挥细胞毒性作用特异性杀伤病毒及肿瘤靶细胞参与免疫调节;同时总结了CD8+T淋巴细胞促进巨噬细胞招募且与自然杀伤T淋巴细胞协同参与脂肪组织炎症发展,并通过自身攻击及表观遗传学机制导致肝损伤,促进NASH发病。由此得知CD8+T淋巴细胞可能成为NASH新的治疗靶点,未来继续深入研究CD8+T淋巴细胞在NASH中影响发病进程的具体机制有利于进一步指导临床治疗。

     

  • 图  1  NASH中CD8+T淋巴细胞的作用机制

    Figure  1.  Mechanism of CD8+T cells in NASH

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  • 收稿日期:  2024-01-29
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