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慢性丙型肝炎患者经抗病毒治疗至转氨酶正常后3个月肝硬度达稳定

陈菲凯 魏来 封波 饶慧瑛

引用本文:
Citation:

慢性丙型肝炎患者经抗病毒治疗至转氨酶正常后3个月肝硬度达稳定

DOI: 10.3969/j.issn.1001-5256.2013.10.013
详细信息
  • 中图分类号: R512.63

Liver stiffness becomes stable in patients with chronic hepatitis C three months after ALT normalization due to antiviral therapy

  • 摘要:

    目的探讨ALT升高的慢性丙型肝炎(CHC)患者经抗病毒治疗ALT恢复正常后肝硬度达到稳定的时间。方法从2011年5月起筛查就诊于北京大学人民医院的CHC初治患者,其中ALT升高者纳入研究组,应用FibroScan检测肝硬度;至2012年9月基线入组患者29例,规律抗病毒治疗后定期随访:每4周复查ALT,每8周复查肝硬度,采用自身配对设计,两两比较前后相邻值的变化,直至ALT与肝硬度不再明显改变。前后配对比较采用非参数Wilcoxon检验,重复测量数据的多重比较采用Bonferoni矫正检验水准。两变量相关系数采用Spearman等级相关法。结果随访至抗病毒24周,纳入分析患者24例,ALT中位数在基线、4周、8周、12周、24周分别为64、26、21、20、22 U/L(前后两相邻值比较,P=0.000、0.006、0.337、0.109),即ALT于4周降至正常后继续下降,于8周后稳定;肝硬度中位数在基线、8、16、24周分别为8.7、7.8、6.8、6.7 kPa(前后两相邻值比较,P=0.009、0.001、0.188),即16周前持续下降,16周后未再明显下降。肝硬度于ALT恢...

     

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  • 收稿日期:  2013-02-28
  • 出版日期:  2013-10-20
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