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两种途径移植自体骨髓干细胞治疗肝硬化患者的疗效比较

王方 寇俊峰 云升皓 蔡国芳 王可敬 杨兴坤

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两种途径移植自体骨髓干细胞治疗肝硬化患者的疗效比较

DOI: 10.3969/j.issn.1001-5256.2013.11.011
详细信息
  • 中图分类号: R575.2

Therapeutic effect of autologous bone marrow stem cell transplantation through portal vein or hepatic artery in treatment of decompensated liver cirrhosis: a comparative study

  • 摘要: 目的比较经肝动脉和门静脉移植自体骨髓干细胞治疗失代偿期肝硬化患者的疗效和安全性。方法回顾性分析2006年12月至2012年5月50例住院患者资料,门静脉治疗组失代偿期肝硬化患者25例和肝动脉治疗组25例,两组基线特征差异无统计学意义。门静脉治疗组在基础治疗基础上在超声介入下经皮经肝穿刺至门静脉,注入自体骨髓干细胞治疗;肝动脉治疗组在基础治疗基础上在放射介入下经股动脉插管至肝固有动脉注入自体骨髓干细胞治疗。治疗后第2、4、8周检测两组患者ALT、AST、TBil、凝血酶原活动度(PTA)和白蛋白(Alb)水平变化。同时观察临床症状的改善情况及术后的不良反应。组间比较采用成组t检验,治疗前后比较采用配对t检验,计数资料采用卡方检验。结果门静脉组有22例(88.0%)患者乏力、纳差症状有明显改善,肝动脉组有21例(84.0%),两组间比较差异无统计学意义(P>0.05);治疗后8周,门静脉和肝动脉组患者血清Alb水平分别为(34.4±7.8)g/L和(33.8±8.0)g/L,较治疗前[分别为(27.1±8.9)g/L和(26.8±9.6)g/L]有显著提升(P均<0.05),但...

     

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  • 收稿日期:  2013-02-08
  • 出版日期:  2013-11-20
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