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瞬时弹性成像在诊断HBeAg阴性慢性乙型肝炎肝纤维化中的价值

罗俊华 巴元明

引用本文:
Citation:

瞬时弹性成像在诊断HBeAg阴性慢性乙型肝炎肝纤维化中的价值

DOI: 10.3969/j.issn.1001-5256.2014.07.011
基金项目: 

国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2012052); 

详细信息
  • 中图分类号: R512.62;R575.2

Value of FibroScan in diagnosis of hepatic fibrosis in patients with HBeAg-negative chronic hepatitis B

Research funding: 

 

  • 摘要: 目的探讨肝脏瞬时弹性成像(FibroScan,FS)在HBeAg阴性慢性乙型肝炎(CHB)患者肝纤维化中的应用价值。方法选择2011年6月-2013年5月在湖北省中医院诊治的HBeAg阴性CHB患者104例,运用FS进行肝脏硬度(Stiffness值)测量,所有患者均行肝穿刺活组织检查。以肝活组织检查病理结果为标准,Stiffness值与之对比;同时绘制FS工作特征曲线,计算受试者工作特征曲线下面积(AUC)。组间比较采用Kruskal-Wallis H检验,两组比较采用Mann-Whitney U检验。双变量相关性分析采用Pearson相关和Spearman等级相关法。结果随肝纤维化程度的提高,Stiffness值逐渐增高,差异有统计学意义(P<0.01或P<0.05)。Stiffness值与肝纤维化分期呈正相关(r=0.810,P<0.01)。FS检测肝硬化AUC为0.956,其中以13.1 kPa作为肝硬化的诊断界值,敏感度为92.7%,特异度为80%。结论 FS在HBeAg阴性CHB患者肝纤维化程度的评估中具有较好的应用价值,尤其诊断肝硬化的准确性较高,直接、...

     

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  • 收稿日期:  2013-12-09
  • 出版日期:  2014-07-20
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