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以亚急性肝衰竭为首发表现的IgG4相关性自身免疫性肝炎1例报告

蒋黎 刘慧敏 毛青

引用本文:
Citation:

以亚急性肝衰竭为首发表现的IgG4相关性自身免疫性肝炎1例报告

DOI: 10.3969/j.issn.1001-5256.2022.01.028
基金项目: 

国家科技重大专项 (2017ZX10203201-006);

国家科技重大专项 (2017ZX10202201-00-010)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:刘慧敏负责文章设计,病例资料分析,撰写论文; 蒋黎参与收集数据,修改论文; 毛青负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    刘慧敏,liuhuimin_412@sina.cn

IgG4-related autoimmune hepatitis with subacute liver failure as the initial manifestation: A case report

Research funding: 

the Major Program of National Science and Technology (2017ZX10203201-006);

the Major Program of National Science and Technology (2017ZX10202201-00-010)

  • 图  1  肝组织活检病理

    注:a,汇管区炎症,界面炎(HE染色,×400);b,多小叶坏死(HE染色,×100);c,IgG染色(×400);d,IgG4染色(×400); e,网染(×200);f,电镜(×4000);g,电镜(×2000);h,电镜(×2000)。

    图  2  IgG与IgG4随访情况

    表  1  血生化指标随访情况

    时间 ALT(U/L) AST(U/L) GGT(U/L) ALP(U/L) Alb(g/L) TBil(μmol/L) DBil(μmol/L) PT-INR PLT(×109/L)
    2021/2/8 717 1220 348 553 22.10 305.18 222.97 1.19 94
    2021/2/13 228 251 247 370 25.26 301.68 212.30 1.63 97
    2021/2/24 165 259 261 390 33.8 436.35 326.05 1.70 98
    2021/3/4 107 109 237 229 29.43 233.89 179.00 1.41 41
    2021/3/11 72 89 233 192 31.01 152.01 114.50 1.32 65
    2021/3/15 71 84 254 215 30.50 124.40 82.75 1.49 70
    2021/4/3 75 386 385 350 22.00 158.30 115.80 1.34 73
    2021/4/8 101 391 302 335 29.50 169.00 108.60 1.50 65
    2021/4/16 102 120 235 240 31.20 138.40 88.90 1.48 79
    2021/4/22 79 79 192 198 25.30 134.70 98.50 1.22 73
    2021/4/27 59 58 160 146 29.70 87.70 65.80 1.46 65
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    中华医学会肝病学分会, 中华医学会消化病学分会, 中华医学会感染病学分会. 自身免疫性肝炎诊断和治疗共识(2015)[J]. 临床肝胆病杂志, 2016, 32(1): 9-22. DOI: 10.3969/j.issn.1001-5256.2016.01.002.
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    中华医学会感染病学分会肝衰竭与人工肝学组. 肝衰竭诊治指南(2018年版)[J]. 临床肝胆病杂志, 2019, 35(1): 38-44. DOI: 10.3969/j.issn.1001-5256.2019.01.007.
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出版历程
  • 收稿日期:  2021-05-12
  • 录用日期:  2021-05-31
  • 出版日期:  2022-01-20
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