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靶向自噬缓解肝缺血再灌注损伤的研究进展

李振 王科 王凯强 俞科贤

引用本文:
Citation:

靶向自噬缓解肝缺血再灌注损伤的研究进展

DOI: 10.3969/j.issn.1001-5256.2022.01.037
基金项目: 

国家中医药管理局——全国中医药创新骨干人才培训项目 (Chinese Medicine Education Letter〔2019〕 No.128);

教育部“春晖计划”科技项目 (Z2017038)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:李振负责课题设计,资料分析,撰写论文;李振、王科、王凯强参与收集数据,修改论文;俞科贤、李振负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    俞科贤,ykx0421@163.com

    作者说明:李振和王科同为第一作者

Research advances in targeting autophagy to alleviate hepatic ischemia-reperfusion injury

Research funding: 

State Administration of Traditional Chinese Medicine-National Training Program for Innovative Key Talents of Traditional Chinese Medicine (Chinese Medicine Education Letter〔2019〕 No.128);

Science and Technology Project of "Chunhui Plan" of Ministry of Education (Z2017038)

  • 摘要: 肝缺血再灌注损伤(HIRI)是肝切除和肝移植术后常见的临床问题,是导致移植术后肝功能障碍和肝功能衰竭的主要原因。近年来,自噬介导的途径成为缓解HIRI的研究热点。自噬是指细胞通过将大量细胞质、受损细胞器等底物运输到溶酶体内进行消化降解以不断更新重塑再利用细胞的过程。本文从基因、蛋白、信号通路、炎症反应、氧化应激反应、线粒体及内质网应激等方面总结了靶向自噬途径缓解HIRI相关机制的研究进展,并围绕研究中存在的问题进行了讨论和展望,以期为今后通过靶向自噬途径缓解HIRI的研究提供理论支持。

     

  • 图  1  提高HIRI中自噬水平的机制

    图  2  降低HIRI中自噬水平的机制

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  • 收稿日期:  2021-06-20
  • 录用日期:  2021-08-13
  • 出版日期:  2022-01-20
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