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自身免疫性肝炎发病机制进展与临床干预新靶点

胡明礼 王绮夏 马雄

引用本文:
Citation:

自身免疫性肝炎发病机制进展与临床干预新靶点

DOI: 10.3969/j.issn.1001-5256.2022.04.002
基金项目: 

国家自然科学基金 (82130017)

国家自然科学基金 (82070581)

国家自然科学基金 (81790634)

上海市卫生计生系统优秀青年医学人才培养计划 (2017YQ037)

上海市青年科技启明星计划 (18QA1402700)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:胡明礼负责查找文献、分析资料、撰写文稿;马雄和王绮夏负责确定写作思路、指导文章撰写及最后定稿。
详细信息
    通信作者:

    王绮夏,wqx0221155@126.com

    马雄,maxiongmd@163.com

Advances in the pathogenesis of autoimmune hepatitis and new targets for clinical intervention

Research funding: 

National Natural Science Foundation of China (82130017);

National Natural Science Foundation of China (82070581);

National Natural Science Foundation of China (81790634);

The Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ037);

Shanghai Rising-Star Program (18QA1402700)

More Information
  • 摘要: 自身免疫性肝炎(AIH)是一种以肝细胞受损为主的免疫介导性肝病,以高免疫球蛋白G血症及自身抗体阳性为特征,组织学可见汇管区大量淋巴-浆细胞浸润所致的界面性肝炎。AIH发病机制尚未完全阐明,目前主要以糖皮质激素联合硫唑嘌呤进行非特异性免疫抑制治疗,多数患者应答良好。但在药物减量过程中以及停药后容易出现反跳或复发,故而大多数患者需长期维持治疗。本文就AIH发病机制进展及临床干预的潜在新靶点进行简要综述,以期为临床转化研究提供参考。

     

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  • 收稿日期:  2021-11-30
  • 录用日期:  2022-01-13
  • 出版日期:  2022-04-20
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