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抗-HAV-IgM阳性的自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征1例报告

何艳莎 刘华宝 宋翊 陈新瑜 饶春燕

引用本文:
Citation:

抗-HAV-IgM阳性的自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征1例报告

DOI: 10.3969/j.issn.1001-5256.2022.04.025
基金项目: 

重大疑难疾病(肝纤维化)中西医临床协作试点项目 (Department of Medicine, State Adminstration of Traditional Chinese Medicine(2018)No.3)

重庆市技术创新与应用发展专项重点项目 (cstc2019jscx-dxwtBX0023)

重庆市自然科学基金 (cstc2020jcyj-msxmX0630)

重庆卫生健康委员会、重庆市科学技术局联合中医药科研项目 (2019ZY3202)

化理学声明:本例报告已获得患者知情同意。
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:何艳莎、饶春燕负责课题设计,资料分析,撰写论文;何艳莎参与收集数据,修改论文;宋翊、陈新瑜、刘华宝负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    饶春燕,chunyanrao@126.com

A case of anti-HAV-IgM-positive AIH-PBC overlap syndrome

Research funding: 

Pilot Project of Clinical Coopetation of Traditional Chinese and Western Medicine in Major Difficult Diseases(Liver Fibrosis) (Department of Medicine, State Adminstration of Traditional Chinese Medicine(2018)No.3);

Special Key Projects of Technological innovation and Application Development in Chongqing (cstc2019jscx-dxwtBX0023);

Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0630);

Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau) (2019ZY3202)

More Information
  • 图  1  肝穿刺病理结果(HE染色,×200)

    注:a,汇管区明显扩大,较多淋巴细胞、中性粒细胞、浆细胞浸润,中重度界面炎,可见小胆管损伤及桥接坏死;b,胆管上皮CK19阳性,可见轻-中度细胆管增生;c,IgG阳性,25个/HPF。

    Figure  1.  Pathological results of liver puncture (hematoxylin-eosin staining, × 200)

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    吴孟超, 李梦东. 实用肝脏病学[M]. 北京: 人民卫生出版社, 2011: 228.
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    [11] ABE K, KANNO Y, OKAI K, et al. Centrilobular necrosis in acute presentation of Japanese patients with type 1 autoimmune hepatitis[J]. World J Hepatol, 2012, 4(9): 262-267. DOI: 10.4254/wjh.v4.i9.262.
    [12] OZASLAN E, EFE C, HEURGUÉ-BERLOT A, et al. Factors associated with response to therapy and outcome of patients with primary biliary cirrhosis with features of autoimmune hepatitis[J]. Clin Gastroenterol Hepatol, 2014, 12(5): 863-869. DOI: 10.1016/j.cgh.2013.09.021.
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  • 收稿日期:  2021-07-27
  • 出版日期:  2022-04-20
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