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虎杖活性成分治疗非酒精性脂肪性肝病的相关信号通路及相互作用

李淑娣 陈欣菊 刘江凯 王振 段飞 袁卓雅 梁磊 李素领

引用本文:
Citation:

虎杖活性成分治疗非酒精性脂肪性肝病的相关信号通路及相互作用

DOI: 10.3969/j.issn.1001-5256.2022.04.033
基金项目: 

国家科技重大专项 (2018ZX10303502);

国家自然科学基金(联合基金) (U1504825);

河南省中医管理局科研专项 (20-21ZY1011)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:李淑娣负责课题设计,资料分析; 陈欣菊、刘江凯、王振、段飞负责修改论文; 袁卓雅、梁磊负责归纳总结文献资料; 李素领负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    李素领,hk-lsl@163.com

Signaling pathways involved in the active components of Polygonum cuspidatum in treatment of nonalcoholic fatty liver disease and their interaction

Research funding: 

National Science and Technology Major Project (2018ZX10303502)

National Natural Science Foundation of China (Joint Fund) (U1504825)

Scientific Research Special Project of Henan Administration of Traditional Chinese Medicine (20-21ZY1011)

More Information
    Corresponding author: LI Suling, hk-lsl@163.com(ORCID: 0000-0002-5211-1330)
  • 摘要: 非酒精性脂肪性肝病(NAFLD)的发病机制尚不清楚,且目前尚无任何治疗NAFLD的有效药物获批。虎杖是药用历史悠久的天然中药,研究证实其在治疗NAFLD中可发挥重要作用。本文通过梳理近年来虎杖活性成分应用于NAFLD的相关研究成果,可见虎杖活性成分通过调控核因子E2相关因子2、腺苷酸活化蛋白激酶、NF-κB、沉默信息调节因子1和过氧化物酶体增殖物激活受体α等多条相关信号通路,发挥改善胰岛素抵抗、抗氧化应激、调节脂质代谢、改善内质网应激、减轻炎症浸润等作用,达到防治NAFLD的作用,以期为NAFLD治疗药物研发及机制探索提供依据和思路。

     

  • 图  1  虎杖活性成分治疗NAFLD的细胞信号通路机制

    Figure  1.  Mechanism of cell signaling pathway in treatment of NAFLD by active ingredients of Polygonum cuspidatum

    表  1  虎杖活性成分调节Nrf2通路作用于NAFLD的效应路径

    Table  1.   Active ingredients of Polygonum cuspidatum regulates the effect pathway of Nrf2 pathway on NAFLD

    路径 效应指标
    抗氧化应激 SOD、GSH、CAT↑; MDA↓
    调节脂质代谢 HO-1、CPT1↑
    减轻炎症反应 TNFα、IL-1β、IL-6↓
    注:↑上调; ↓下调。
    下载: 导出CSV

    表  2  虎杖活性成分调节AMPK通路作用于NAFLD的效应路径

    Table  2.   Active ingredients of Polygonum cuspidatum regulates the pathway of AMPK pathway on NAFLD

    路径 效应指标
    调节脂质代谢 PPARα、SREBP-1c、ChREBP↑; FASN、SCD1↓
    改善胰岛素抵抗 脂联素↑
    减轻炎症反应 SREBP-1c↓
    注:↑上调; ↓下调。FASN,脂肪酸合酶; SCD1,硬脂酰辅酶A去饱合酶1。
    下载: 导出CSV

    表  3  虎杖活性成分调节NF-κB通路作用于NAFLD的效应路径

    Table  3.   Active ingredients of Polygonum cuspidatum regulates the pathway of NF-κB pathway on NAFLD

    路径 效应指标
    减轻炎症反应 TNFα、IL-1β、IL-6↓
    改善胰岛素抵抗 ERK、IL-6、TNFα、LPS↓
    注:↓下调。
    下载: 导出CSV

    表  4  虎杖活性成分调节SIRT1通路作用于NAFLD的效应路径

    Table  4.   Active ingredients of Polygonum cuspidatum regulates the pathway of SIRT1 pathway on NAFLD

    路径 效应指标
    调节脂质代谢 ATF6、LC3↓; GLUT4↑
    改善内质网应激 ERK、IL-6、TNFα、LPS↓
    注:↑上调; ↓下调。
    下载: 导出CSV

    表  5  虎杖活性成分调节PPARα通路作用于NAFLD的效应路径

    Table  5.   Active ingredients of Polygonum cuspidatum regulates the pathway of PPARα pathway on NAFLD

    路径 效应指标
    调节脂质代谢 FASN、SCD1↓; PPARα、CPT1↑
    改善氧化应激 PKA、AMPK↑
    注:↑上调; ↓下调。
    下载: 导出CSV
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  • 收稿日期:  2021-07-28
  • 出版日期:  2022-04-20
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