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PM2.5在肝癌发生发展中的作用

左飞 李国东 刘明

引用本文:
Citation:

PM2.5在肝癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2022.04.038
基金项目: 

哈尔滨市应用技术研究与开发项目(优秀学科带头人B类) (2017RAXXJ057)

黑龙江省自然科学基金-联合引导项目 (LH2020H066)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:左飞负责拟定写作思路,查找文献,撰写论文;李国东负责对文章的内容做批判性审阅;刘明参与指导撰写文章并最后定稿。
详细信息
    通信作者:

    刘明,mliu35@aliyun.com

Role of particulate matter 2.5 in the development and progression of liver cancer

Research funding: 

Harbin Applied Technology Research and Development Project (Excellent Discipline Leader Class B) (2017RAXXJ057);

Natural Science Foundation of Heilongjiang Province-Joint Guidance Project (LH2020H066)

More Information
  • 摘要: 平均空气动力学直径≤2.5 μm的颗粒物(PM2.5)作为大气颗粒物的主要成分之一,已经成为影响人们健康的重要因素,然而针对PM2.5与肝癌发生发展关系的研究相对较少。回顾了PM2.5与肝癌发病的流行病学研究,总结了PM2.5引起肝癌的相关机制,包括改变酶活性,影响基因表达,诱导内质网应激,引起肝脂肪变性和导致肝纤维化等,同时讨论了PM2.5暴露对肝癌预后的影响。

     

  • 图  1  PM2.5影响肝癌的机制示意图

    注:IRS,胰岛素受体底物;AKT,蛋白激酶B;ATF-6,活化转录因子6;PERK, 蛋白激酶R样内质网激酶;IRE1,肌醇需求酶1;TRAF2,肿瘤坏死因子相关受体因子2;JNK,氨基末端激酶。

    Figure  1.  Schematic diagram of the mechanism of PM2.5 affecting liver cancer

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  • 收稿日期:  2021-08-20
  • 录用日期:  2021-10-08
  • 出版日期:  2022-04-20
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