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胰腺癌肿瘤微环境的机制及靶向治疗

张艺译 徐敏

引用本文:
Citation:

胰腺癌肿瘤微环境的机制及靶向治疗

DOI: 10.3969/j.issn.1001-5256.2022.04.046
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:张艺译负责收集资料,分析文献,撰写论文;徐敏负责拟定写作思路,指导撰写文章并最后定稿。
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    通信作者:

    徐敏,xumin73@126.com

Research advances in the mechanism of tumor microenvironment in pancreatic cancer and related targeted therapy

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    Corresponding author: XU Min, xumin73@126.com(ORCID: 0000-0003-3224-9348)
  • 摘要: 胰腺癌肿瘤微环境是一个包含胰腺星状细胞、癌相关成纤维细胞、免疫细胞和细胞外基质的过度纤维化的致密基质环境,不仅为肿瘤创造了促进其生长和侵袭的环境,并使其对化疗和其他抗肿瘤药物产生耐受抵抗。基质中密集纤维化反应和肿瘤在免疫环境中的改变被认为是目前胰腺癌治疗失败的主要原因。本文回顾了近年来胰腺癌肿瘤微环境相关研究进展,对其组成成分和致病机制以及针对基质和免疫的靶向治疗作一综述,分析肿瘤微环境对胰腺癌发生进展的重要性及其在靶向治疗方面的影响。

     

  • 图  1  胰腺癌TME细胞成分作用机制图

    Figure  1.  Mechanism of TME cellular components in pancreatic cancer

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出版历程
  • 收稿日期:  2021-08-14
  • 录用日期:  2021-09-26
  • 出版日期:  2022-04-20
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