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肠-肝轴:肠道微生物稳态与肝细胞癌

周荃 蔡春琳 李金强

引用本文:
Citation:

肠-肝轴:肠道微生物稳态与肝细胞癌

DOI: 10.3969/j.issn.1001-5256.2023.11.029
基金项目: 

湖南省卫生健康委科研计划项目 (20200163);

湖南省卫生健康委科研计划项目 (202103081037)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:周荃负责拟定写作思路,检索文献,撰写及修改论文;李金强、蔡春琳负责指导,最终定稿。
详细信息
    通信作者:

    蔡春琳, 1537983535@qq.com (ORCID: 0000-0001-6550-4187)

    李金强, leejy2020@163.com (ORCID: 0000-0001-9913-1622)

Gut-liver axis: Intestinal microbial homeostasis and hepatocellular carcinoma

Research funding: 

Scientific Research Program of Hunan Provincial Health Commission (20200163);

Scientific Research Program of Hunan Provincial Health Commission (202103081037)

More Information
  • 摘要: 肠道微生物群在维持肝脏代谢稳态中扮演重要角色,其通过参与胆汁酸代谢影响肝细胞癌的发生发展。“肠-肝轴”在肝脏疾病发病机制中占据举足轻重的地位,通过纠正肠道生态失衡以恢复正常胆汁酸水平,可能是阻止肝细胞癌进展的有效方法之一。本文总结了胆汁酸受体影响肝细胞癌的相关机制以及最新治疗靶点,旨在为早期防治肝癌提供参考依据。

     

  • 图  1  肠-肝轴示意图

    注: BSH,胆盐水解酶;LCA,石胆酸;DCA,脱氧胆酸;LPS,脂多糖;TLR4, Toll样受体4。

    Figure  1.  Schematic Diagram of Gut-Liver Axis

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