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淀粉样蛋白在肝脏中的生理病理作用

宗也凯 刘江凯

引用本文:
Citation:

淀粉样蛋白在肝脏中的生理病理作用

DOI: 10.3969/j.issn.1001-5256.2023.11.031
基金项目: 

国家自然科学基金 (U1504825)

河南省中医药拔尖人才项目 (Yuwei TCM letter 2021-15)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:宗也凯负责论文设计,撰写论文;刘江凯参与论文指导。
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    通信作者:

    刘江凯, 13592553982@126.com (ORCID: 0000-0002-1529-5089)

The physiological and pathological role of amyloid protein in the liver

Research funding: 

National Natural Science Foundation of China (U1504825);

Henan TCM Top-notch Talent Program (Yuwei TCM letter 2021-15)

More Information
  • 摘要: 淀粉样蛋白被用来描述因蛋白质错误折叠而形成的纤维状聚集体,它与一系列淀粉样变性疾病有关。当淀粉样蛋白沉积在肝脏,就会导致肝淀粉样变性,从而诱发相关病理改变影响肝脏正常生理功能,但这一疾病少有报道且临床常常被忽视。本文主要讨论了淀粉样蛋白在肝脏中的生理病理作用及机制,以便于加深对淀粉样蛋白相关疾病的理解并为相关研究和临床治疗提供一定参考。

     

  • 表  1  不同器官淀粉样变性临床表现1

    Table  1.   Clinical manifestations of amyloidosis in different organs1

    器官 应怀疑淀粉样变的临床体征和症状
    肝肿大,早饱,明显无意的体质量减轻,出血性疾病
    呼吸短促,端坐呼吸,阵发性夜间呼吸困难,颈静脉扩张,外周水肿,心律失常
    外周水肿
    胃肠道 排便习惯不规律,早饱,体质量减轻,胃肌轻瘫,吞咽困难,胃肠出血
    周围神经 长度相关的对称周边神经病变,自主神经病变(勃起功能障碍、体位性高血压、排尿功能障碍、早饱、排便不规则习惯)
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  • 收稿日期:  2023-02-07
  • 录用日期:  2023-03-08
  • 出版日期:  2023-11-28
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