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2017年AGA指南更新:丙型肝炎治疗血清学应答患者的临床管理

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发布日期:2017-03-23
英文标题:AGA Institute Clinical Practice Update: Care of Patients Who Have Achieved a Sustained Virologic Response (SVR) Following Antiviral Therapy for Chronic Hepatitis C Infection
来源:Gastroenterology, 2017
制定者:美国胃肠病学会(AGA)

      Chronic hepatitis C virus (HCV) infection is well-recognized as a common blood borne infection with global public health impact, affecting 3 to 5 million persons in the U.S. and over 170 million persons worldwide. Chronic HCV infection is associated with significant morbidity and mortality due to complications of liver cirrhosis and hepatocellular carcinoma (HCC). Current therapies with all-oral directly acting antiviral agents (DAAs) are associated with high rates of sustained virologic response (SVR), generally exceeding 90%. SVR is associated with a reduced risk of liver cirrhosis, hepatic decompensation, need for liver transplantation, and both liver-related and all-cause mortality. However, a subset of patients who achieve SVR will remain at long-term risk for progression to cirrhosis, liver failure, HCC, and liver-related mortality. Limited evidence is available to guide clinicians on which post-SVR patients should be monitored versus discharged, how to monitor and with which tests, how frequently should monitoring occur, and for how long. In this clinical practice update, available evidence and expert opinion are used to generate best practice recommendations on the care of patients with chronic HCV who have achieved SVR.

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阅读次数:1265
  • 1 病毒性肝炎
    • 1.1 乙型肝炎
    • 1.2 丙型肝炎
    • 1.3 甲型肝炎
    • 1.4 戊型肝炎
    • 1.5 其他肝炎
  • 2 肝硬化及并发症
  • 3 酒精性肝病
  • 4 非酒精性脂肪性肝病
  • 5 肝衰竭/肝性脑病/人工肝
  • 6 肝肿瘤
  • 7 自身免疫性肝病
  • 8 药物性肝病
  • 9 肝移植
  • 10 其他肝病
    • 10.1 遗传及代谢性肝病
    • 10.2 胆汁淤积性肝病
    • 10.3 肝脏血管病
  • 11 一般肝病/肝脏检查
  • 12 胆道疾病
  • 13 胰腺疾病
  • 14 全身疾病与肝病/内镜
  • 15 肝胆胰疾病相关评分系统汇总