对于胰腺癌的患者,我们很少去关注他们从确诊至离世的住院天数及治疗天数。使用美国国家癌症研究所的SEER数据库(监督,流行病学和最终结果),选取1992-2005年25476名胰腺癌患者,按照不同的癌症阶段、治疗方式和存活时间分组,对每位患者每月的住院天数及治疗天数进行统计分析。 对于不同生存时间和不同治疗方案的胰腺癌患者,其“住院/治疗天数”是不同的。在确诊后的第1个月里,患者平均住院时间为6.4天,总接受治疗时间为9.0天,以后逐月下降,至第12个月,患者住院时间与治疗时间分别为1.7天和3.7天。生存期短的胰腺癌患者每月“住院/治疗天数”较长。但无论患者生存期长短,所有胰腺癌晚期的患者“住院/治疗时间”明显增加。 手术切除局限病灶的患者,在确诊后的前4个月里,他们的“住院/治疗天数”较长,而在接受诊治一年后,他们的“住院/治疗天数”缩短。对于已经有远处转移的胰腺癌患者,其住院天数相似。而接受化疗的患者,其治疗天数延长,这在晚期患者更加明显。这项研究首次按照不同的癌症阶段、治疗方式和存活时间,对胰腺癌患者的“住院/治疗天数”进行量化分析。研究结果提示了切实的期望值,为患者选择个性化医疗方式提供参考。
吉林大学第一医院肝胆胰内科 赵 旭 高普均 摘译
本文首次发表于[Annals of Surgical Oncology 2012 , 19(8): 2435–2442 ]
Hospital and Medical Care Days in Pancreatic Cancer
Background Little is known about resource utilization (number of days in the hospital or medical care) between diagnosis and death in patients with pancreatic cancer. Methods Using Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data, we identified 25,476 patients with pancreatic cancer (1992-2005). Hospital and medical care days per person-month from the time of diagnosis were described, stratified by stage, treatment, and survival duration. Results Hospital/medical care days vary by length of survival and treatment strategy in patients with pancreatic cancer. For all stages, patients were in the hospital a mean of 6.4 days and received medical care a total of 9.0 days in the first month after diagnosis, decreasing to 1.7 and 3.7 days per month, respectively, by the end of the first year. Hospital/medical care days per month of life were higher in patients with shorter survival but increased sharply at the end of life in all patients, regardless of duration of survival. In patients with locoregional disease, resection was associated with a higher number of hospital/medical care days during the first 4 months after diagnosis, but fewer at the end of the first year. For distant disease, hospital days were similar but days in medical care were higher for patients receiving chemotherapy, increasing especially at the end of life. Conclusions This study is the first to quantify hospital/ medical care days in patients with pancreatic cancer by stage, treatment, and survival. This information will provide realistic expectations and allow for treatment decisions based on patient preferences.
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