原发性胆汁性肝硬化（PBC）是一种自身免疫性疾病，具有较强的性别偏见，女性发病更多，但仍有小部分PBC患者为男性，为明确男女PBC患者之间的不同特点，我们对中国2386例PBC患者明确了性别分布和年龄，并表述60例男性和462例女性原发性胆汁性肝硬化患者的临床特征。
男性患者的发病年龄为59.0±11.4岁，女性为50.8±9.8岁。两组患者的发病年龄之间存在显著差异（P <0.001）。PBC患者女性占87％，男性占13％；年龄小于29岁组和年龄超过80岁组男性比例高于其他组，分别占39.19％和33.33％。
男性患者比女性患者发生胆结石显著不常见（P<0.05），但男性肝细胞癌（HCC）的发生率高于女性（P<0.05）。男性和女性PBC患者的白细胞、单核细胞、总胆红素、胆碱酯酶，胆固醇和免疫球蛋白M水平存在明显差异。
关于Child-Pugh评分，男性患者在诊断时的MELD评分和MRS评分均高（P<0.001）。男性和女性PBC患者对熊去氧胆酸（UDCA）的生化反应存在显著差异（男性和女性患者分别为44.2％和95.1%）。虽然男性发生PBC的比率比女性少得多，但其病情比女性患者更严重，对熊去氧胆酸生化反应较弱。
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英文原文》》》
The characteristics of different gender of primary biliary cirrhosis
Author：Y.sun;B.Li;Z.zou; Non-infectious liver disease department,302 Military Hospital, Beijing, China.
Primary Biliary Cirrhosis (PBC) is an autoimmune disease with a strong gender bias, occurs more frequently in women, but still a small group of PBC patients are male, in order to determine the different characteristics of PBC between women and men, we clarified the gender dstribution and age in 2386 cases with PBC in China and presenting clinical features of 60 men and 462 women with primary biliary cirrhosis.
The age of the onset occurred 59.0±11.4 years in male, and 50.8±9.8 years in female. Age of onset was significantly different between the two groups(P<0.001).The PBC patients constituted 87% of female, and 13% of male, the ratio of male in the group of younger than 29 and older than 80 year-old were higher than other groups, 39.19% and 33.33% respectively.
Gallstones were significantly less common in men than in women (p
The Child-pugh score, meld score and the MRS score were all higher in men at diagnosis (p
